TY - JOUR

T1 - Optimization and Validation of an LC Method for the Determination of Cefdinir in Dosage Form and Human Urine

AU - Hadad, Ghada M.

AU - Emara, Samy

AU - Mahmoud, Waleed M. M.

PY - 2009/12

Y1 - 2009/12

N2 - A simple and reliable liquid chromatographic method has been developed and validated for the determination of cefdinir in human urine and capsule samples. A chromatographic separation was achieved on a C18 column using a mobile phase consisting of potassium dihydrogen phosphate (10 mM, pH 4.5)–acetonitrile (90:10, v/v). Quantitation was achieved with UV detection at 285 nm, based on peak area with linear calibration curve at a concentration range of 0.7–39 µg mL−1. This method was successfully applied for the establishment of an urinary excretion pattern after oral dose.

AB - A simple and reliable liquid chromatographic method has been developed and validated for the determination of cefdinir in human urine and capsule samples. A chromatographic separation was achieved on a C18 column using a mobile phase consisting of potassium dihydrogen phosphate (10 mM, pH 4.5)–acetonitrile (90:10, v/v). Quantitation was achieved with UV detection at 285 nm, based on peak area with linear calibration curve at a concentration range of 0.7–39 µg mL−1. This method was successfully applied for the establishment of an urinary excretion pattern after oral dose.

KW - Chemistry

KW - Column liquid chromatography

KW - Urinary excretion pattern

KW - Cefdinir

UR - http://www.scopus.com/inward/record.url?scp=72349097752&partnerID=8YFLogxK

U2 - 10.1365/s10337-009-1365-8

DO - 10.1365/s10337-009-1365-8

M3 - Journal articles

VL - 70

SP - 1593

EP - 1598

JO - Chromatographia

JF - Chromatographia

SN - 0009-5893

IS - 11/12

ER -