Health literacy (HL) represents an important determinant of health and is considereda necessary prerequisite for health-promoting behaviour as well as the maintenance andpromotion of health. Strengthening HL is an important aspect of prevention and healthpromotion in the context of (teacher) education and it is partially integrated into theGerman Professional Standards for Teachers. Previous study results of (prospective) teacherspoint to deficient training regarding health-related competencies in the context of theirqualification. Overall, there are too few studies on prospective teachers’ HL and only few thatfocus on the key health-related competencies of HL in the context of prospective teachers’health. Linking this study examined the HL and health status of student teachers (ST) andteacher trainees (TT) and their differences. In addition, the association between the twoconstructs will be elaborated. In this study, 195 ST and 242 TT participated in an onlinesurvey, which used questionnaires to assess HL and health status. The statistical analysis tookinto consideration t-tests, product-moment correlations, and multivariate regression analyses. With the exception of key HL competence communication and cooperation, the other key HLcompetencies were significantly stronger among ST. In contrast, TT assessed their healthstatus significantly better. In terms of correlations, ST and TT abilities to self-regulate playeda leading role. In ST, self-regulation represented the statistically strongest predictor forhealth status, but in TT, proactive approach to health represented the strongest predictor.