Flavonoids as benign substitutes for more harmful synthetic chemicals - effects of flavonoids and their transformation products on algae

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Flavonoids as benign substitutes for more harmful synthetic chemicals - effects of flavonoids and their transformation products on algae. / Schnarr, Lena; Olsson, Oliver; Ohls, Sonia et al.
in: Sustainable Chemistry and Pharmacy, Jahrgang 38, 101473, 01.04.2024.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

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@article{6e55fce551f4496681d5b37df17428f8,
title = "Flavonoids as benign substitutes for more harmful synthetic chemicals - effects of flavonoids and their transformation products on algae",
abstract = "Flavonoids, a group of plant secondary metabolites, are seen as chemicals for pharmaceutical, nutraceutical, and pesticidal applications. Due to their natural origin, anticipated low ecotoxicity and non-persistence in the environment, they are considered as benign substitutes for synthetic chemicals. However, data on ecotoxicity is still scarce. Therefore, this study aimed for a better understanding of the bioactivity of flavonoids and thus allowing a better evaluation of their potential as benign substitutes. The growth inhibition of the microalgae Raphidocelis subcapitata induced by 13 flavonoids, 10 flavonoid mixtures, and 4 flavonoid transformation products was determined according to the OECD guideline 201. EC50 values of flavonoids ranging from 0.7 to 22 mg/L were moderate in comparison to the synthetic algaecides terbutryn and diuron. Mixtures of flavonoids behaved in a dose-addition manner. Moreover, the fate of 11 selected flavonoids during the growth inhibition test was analyzed by analytical methods (HPLC-UV/vis and HPLC-HRMS). Concentration monitoring revealed fast but incomplete degradation of 8 flavonoids. Overall, 25 transformation products of the degrading flavonoids were identified including 5,7-dihydroxychromone. Comparison of structural features indicate that the combination of a methoxy group and a lacking hydroxy group at C3 decreased degradation rates. Growth inhibition of the 4 tested transformation products was weaker than of their respective parent flavonoids. Taken together, the results suggest low ecotoxicity of flavonoids and promote further research towards their utilization as benign substitutes.",
keywords = "Chemistry",
author = "Lena Schnarr and Oliver Olsson and Sonia Ohls and Jolanda Webersinn and Tim Mauch and Klaus K{\"u}mmerer",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors",
year = "2024",
month = apr,
day = "1",
doi = "10.1016/j.scp.2024.101473",
language = "English",
volume = "38",
journal = "Sustainable Chemistry and Pharmacy",
issn = "2352-5541",
publisher = "Elsevier B.V.",

}

RIS

TY - JOUR

T1 - Flavonoids as benign substitutes for more harmful synthetic chemicals - effects of flavonoids and their transformation products on algae

AU - Schnarr, Lena

AU - Olsson, Oliver

AU - Ohls, Sonia

AU - Webersinn, Jolanda

AU - Mauch, Tim

AU - Kümmerer, Klaus

N1 - Publisher Copyright: © 2024 The Authors

PY - 2024/4/1

Y1 - 2024/4/1

N2 - Flavonoids, a group of plant secondary metabolites, are seen as chemicals for pharmaceutical, nutraceutical, and pesticidal applications. Due to their natural origin, anticipated low ecotoxicity and non-persistence in the environment, they are considered as benign substitutes for synthetic chemicals. However, data on ecotoxicity is still scarce. Therefore, this study aimed for a better understanding of the bioactivity of flavonoids and thus allowing a better evaluation of their potential as benign substitutes. The growth inhibition of the microalgae Raphidocelis subcapitata induced by 13 flavonoids, 10 flavonoid mixtures, and 4 flavonoid transformation products was determined according to the OECD guideline 201. EC50 values of flavonoids ranging from 0.7 to 22 mg/L were moderate in comparison to the synthetic algaecides terbutryn and diuron. Mixtures of flavonoids behaved in a dose-addition manner. Moreover, the fate of 11 selected flavonoids during the growth inhibition test was analyzed by analytical methods (HPLC-UV/vis and HPLC-HRMS). Concentration monitoring revealed fast but incomplete degradation of 8 flavonoids. Overall, 25 transformation products of the degrading flavonoids were identified including 5,7-dihydroxychromone. Comparison of structural features indicate that the combination of a methoxy group and a lacking hydroxy group at C3 decreased degradation rates. Growth inhibition of the 4 tested transformation products was weaker than of their respective parent flavonoids. Taken together, the results suggest low ecotoxicity of flavonoids and promote further research towards their utilization as benign substitutes.

AB - Flavonoids, a group of plant secondary metabolites, are seen as chemicals for pharmaceutical, nutraceutical, and pesticidal applications. Due to their natural origin, anticipated low ecotoxicity and non-persistence in the environment, they are considered as benign substitutes for synthetic chemicals. However, data on ecotoxicity is still scarce. Therefore, this study aimed for a better understanding of the bioactivity of flavonoids and thus allowing a better evaluation of their potential as benign substitutes. The growth inhibition of the microalgae Raphidocelis subcapitata induced by 13 flavonoids, 10 flavonoid mixtures, and 4 flavonoid transformation products was determined according to the OECD guideline 201. EC50 values of flavonoids ranging from 0.7 to 22 mg/L were moderate in comparison to the synthetic algaecides terbutryn and diuron. Mixtures of flavonoids behaved in a dose-addition manner. Moreover, the fate of 11 selected flavonoids during the growth inhibition test was analyzed by analytical methods (HPLC-UV/vis and HPLC-HRMS). Concentration monitoring revealed fast but incomplete degradation of 8 flavonoids. Overall, 25 transformation products of the degrading flavonoids were identified including 5,7-dihydroxychromone. Comparison of structural features indicate that the combination of a methoxy group and a lacking hydroxy group at C3 decreased degradation rates. Growth inhibition of the 4 tested transformation products was weaker than of their respective parent flavonoids. Taken together, the results suggest low ecotoxicity of flavonoids and promote further research towards their utilization as benign substitutes.

KW - Chemistry

UR - http://www.scopus.com/inward/record.url?scp=85185455063&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/b8856896-6e98-33a6-b17f-cb926688424c/

U2 - 10.1016/j.scp.2024.101473

DO - 10.1016/j.scp.2024.101473

M3 - Journal articles

VL - 38

JO - Sustainable Chemistry and Pharmacy

JF - Sustainable Chemistry and Pharmacy

SN - 2352-5541

M1 - 101473

ER -

DOI

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