TY - JOUR

T1 - Estimation of human body concentrations of DDT from indoor residual spraying for malaria control

AU - Gyalpo, Tenzing

AU - Fritsche, Lukas

AU - Bouwman, Henk

AU - Bornman, Riana

AU - Scheringer, Martin

AU - Hungerbühler, Konrad

PY - 2012/10

Y1 - 2012/10

N2 - Inhabitants of dwellings treated with DDT for indoor residual spraying show high DDT levels in blood and breast milk. This is of concern since mothers transfer lipid-soluble contaminants such as DDT via breastfeeding to their children. Focusing on DDT use in South Africa, we employ a pharmacokinetic model to estimate DDT levels in human lipid tissue over the lifetime of an individual to determine the amount of DDT transferred to children during breastfeeding, and to identify the dominant DDT uptake routes. In particular, the effects of breastfeeding duration, parity, and mother's age on DDT concentrations of mother and infant are investigated. Model results show that primiparous mothers have greater DDT concentrations than multiparous mothers, which causes higher DDT exposure of first-born children. DDT in the body mainly originates from diet. Generally, our modeled DDT levels reproduce levels found in South African biomonitoring data within a factor of 3.

AB - Inhabitants of dwellings treated with DDT for indoor residual spraying show high DDT levels in blood and breast milk. This is of concern since mothers transfer lipid-soluble contaminants such as DDT via breastfeeding to their children. Focusing on DDT use in South Africa, we employ a pharmacokinetic model to estimate DDT levels in human lipid tissue over the lifetime of an individual to determine the amount of DDT transferred to children during breastfeeding, and to identify the dominant DDT uptake routes. In particular, the effects of breastfeeding duration, parity, and mother's age on DDT concentrations of mother and infant are investigated. Model results show that primiparous mothers have greater DDT concentrations than multiparous mothers, which causes higher DDT exposure of first-born children. DDT in the body mainly originates from diet. Generally, our modeled DDT levels reproduce levels found in South African biomonitoring data within a factor of 3.

KW - Biology

KW - DDT

KW - Indoor residual spraying

KW - Human exposure modeling

KW - infant exposure

KW - reproductive characteristics

UR - http://www.scopus.com/inward/record.url?scp=84863808498&partnerID=8YFLogxK

U2 - 10.1016/j.envpol.2012.04.032

DO - 10.1016/j.envpol.2012.04.032

M3 - Journal articles

C2 - 22682611

VL - 169

SP - 235

EP - 241

JO - Environmental Pollution

JF - Environmental Pollution

SN - 0269-7491

ER -