Recommendations for evaluating temporal trends of persistent organic pollutants in breast milk

Publikation: Beiträge in ZeitschriftenKommentare / Debatten / BerichteForschung

Authors

Background: Biomonitoring data of persistent organic pollutants (POPs) in breast milk are increasingly collected and available for quantitative analysis of levels and time trends. A common approach is to apply log-linear regression to calculate doubling and halving times of the POP concentrations based on the temporal trend observed in breast milk. However, there are different, sometimes conflicting interpretations of these doubling and halving times. Objectives: We provide a mechanistic understanding of doubling and halving times where possible. Five recommendations are proposed for dealing with POP concentration trends in breast milk during three distinct periods (pre-ban, transition, post-ban period). Discussion: Using temporal trends of BDE-47 and PCB-153 in breast milk data, we show which information can be gained from the time-trend data. To this end, we analyzed time trends of hypothetical POPs for different periods with time-variant exposure and different intrinsic elimination half-lives, using a dynamic population-based pharmacokinetic model. Different pieces of information can be extracted from time-trend data from different periods. The analysis of trends of shortlived POPs is rather straightforward and facilitates extraction of the intrinsic elimination half-lives from the breast milk data. However, trends of slowly eliminated POPs only provide indications for the exposure time trend. Conclusions: Time-trend data of rapidly eliminated POPs provide information on exposure time trends and elimination half-lives. Temporal trends of slowly eliminated POPs are more complicated to interpret, and the extraction of exposure time trends and elimination half-lives require data sets covering several decades.

OriginalspracheEnglisch
ZeitschriftEnvironmental Health Perspectives
Jahrgang124
Ausgabenummer7
Seiten (von - bis)881-885
Anzahl der Seiten5
ISSN0091-6765
DOIs
PublikationsstatusErschienen - 01.07.2016

DOI

Zuletzt angesehen

Publikationen

  1. Patients' experiences in a guided Internet- and App-based stress intervention for college students
  2. Critical Evaluation of Sustainable Development Goals and Circular Economy in (Business) Education
  3. Limited knowledge flow among stakeholders of critically endangered renosterveld in South Africa
  4. How real options and ecological resilience thinking can assist in environmental risk management
  5. Scenarios for coal-exit in Germany-a model-based analysis and implications in the European context
  6. INFLEXIBLE COMMODITY PRICES AS A RESULT OF PROFIT MAXIMIZATION - REPLY TO A COMMENT BY MAUSSNER,A.
  7. Analyis of a Potential Single and Combined Business Model for Stationary Battery Storage Systems
  8. Estimating the aquatic emissions and fate of perfluorooctane sulfonate (PFOS) into the river Rhine
  9. Changes in butterfly movements along a gradient of land use in farmlands of Transylvania (Romania)
  10. Socioecological drivers facilitating biodiversity conservation in traditional farming landscapes
  11. Characterizing social-ecological units to inform biodiversity conservation in cultural landscapes
  12. Internet- and App-Based Stress Intervention for Distance-Learning Students With Depressive Symptoms
  13. Abfallvermeidungsprogramme im neuen Kreislaufwirtschaftsgesetz – ein Beitrag zum Ressourcenschutz?
  14. Can management-sponsored non-binding remuneration votes shape the executive compensation structure?
  15. Credit constraints, idiosyncratic risks, and the wealth ditribution in a heterogeneous agent model
  16. Institutional relatedness and the emergence of renewable energy cooperatives in German districts
  17. Effect of laser peen forming process parameters on bending and surface quality of Ti-6Al-4V sheets
  18. Grenzüberschreitende Hunde- und Hauskatzentransporte innerhalb der EU durch sog. Flugpatenschaften