Trees at Alaskan treelines are assumed to be limited by temperature and to expand upslope and/or to higher latitudes with global warming. However, recent studies describe negative temperature responses and drought stress of Alaskan treeline trees in recent decades. In this study, we have analyzed the responses of treeline white spruce to temperature and precipitation according to different climatic regimes in Alaska, described as negative (cool) and positive (warm) phases of the Pacific Decadal Oscillation (PDO). We found that in three consecutive phases (positive from 192546, negative from 194776, and positive again from 197798), the growth responses to temperature and precipitation differed markedly. Before 1947, in a phase of warm winters and with summer temperatures being close to the century mean, the trees at most sites responded positively to summer temperature, as one would expect from treeline trees at northern high latitudes. Between 1947 and 1976, a phase of cold winters and average summers, the trees showed similar responses, but a new pattern of negative responses to the summer temperature of the year prior to growth coupled with positive responses to the precipitation in the same year emerged at some sites. As the precipitation was relatively low at those sites, we assume that drought stress might have played a role. However, the climate responses were not uniform but were modified by regional gradients (trees at northern sites responded more often to temperature than trees at southern sites) and local site conditions (forest trees responded more often to precipitation than treeline trees), possibly reflecting differences in energy and water balance across regions and sites, respectively. However, since the shift in the PDO in 1976 from a negative to a positive phase, the trees climategrowth responses are much less pronounced and climate seems to have lost its importance as a limiting factor for the growth of treeline white spruce. If predictions of continued warming and precipitation increase at northern high latitudes hold true, the growth of Alaskan treeline trees will likely depend on the ratio of temperature and precipitation increase more than on their absolute values, as well as on the interaction of periodic regime shifts with the global warming trend. Once a climatic limitation is lifted, other factors, such as insect outbreaks or interspecific competition, might become limiting to tree growth.