Building upon the companion paper in this issue, this essay analyses five case studies that can be taken as prototypes of the system-wide cultural district culture-led developmental model. The research targets five cities in Europe and the U.S.: Valencia, Austin, Newcastle/Gateshead, Linz, and Denver. Each presents specific characteristics but also some deep, structural common traits. The case studies are compared and their future viability is evaluated in terms of the factors presented in the companion piece.