TY - JOUR

T1 - Comparing preference-based quality-of-life measures

T2 - Results from rehabilitation patients with musculoskeletal, cardiovascular, or psychosomatic disorders

AU - Moock, Jörn

AU - Kohlmann, Thomas

N1 - MEDLINE® is the source for the MeSH terms of this document.

PY - 2008/4/1

Y1 - 2008/4/1

N2 - ObjectivesTo compare the EQ-5D, 15D, HUI 2, HUI 3, SF-6D, and QWB-SA in terms of their descriptive statistics, score distribution, agreement and responsiveness in a sample of German rehabilitation inpatients.MethodsPatients with musculoskeletal (N = 106), cardiovascular (N = 88), and psychosomatic (N = 70) disorders completed questionnaires at the beginning (baseline) and end (follow-up) of their inpatient treatment. Comparisons addressed the proportion of missing data, distributional properties, agreement, and responsiveness. Intraclass correlation coefficients (ICC), paired t-tests, and standardized response means (SRM) were computed.ResultsMean index scores at baseline ranged from 0.48 (HUI 3; psychosomatic) to 0.86 (15D; cardiovascular). At baseline, ceiling effects across all patient groups ranged from zero (SF-6D; cardiovascular and psychosomatic) to 21.6% (EQ-5D; cardiovascular). ICCs ranged from 0.26 (EQ-5D–QWB-SA; cardiovascular) to 0.80 (HUI 2–HUI 3; musculoskeletal). Substantial differences in responsiveness were observed between measures.ConclusionsResults obtained with different preference-based quality-of-life measures in a sample of patients with mild to moderate disease severity are not equivalent. As differences between measures may have considerable effects in health economic evaluation studies, careful selection of instruments for a given study is essential.

AB - ObjectivesTo compare the EQ-5D, 15D, HUI 2, HUI 3, SF-6D, and QWB-SA in terms of their descriptive statistics, score distribution, agreement and responsiveness in a sample of German rehabilitation inpatients.MethodsPatients with musculoskeletal (N = 106), cardiovascular (N = 88), and psychosomatic (N = 70) disorders completed questionnaires at the beginning (baseline) and end (follow-up) of their inpatient treatment. Comparisons addressed the proportion of missing data, distributional properties, agreement, and responsiveness. Intraclass correlation coefficients (ICC), paired t-tests, and standardized response means (SRM) were computed.ResultsMean index scores at baseline ranged from 0.48 (HUI 3; psychosomatic) to 0.86 (15D; cardiovascular). At baseline, ceiling effects across all patient groups ranged from zero (SF-6D; cardiovascular and psychosomatic) to 21.6% (EQ-5D; cardiovascular). ICCs ranged from 0.26 (EQ-5D–QWB-SA; cardiovascular) to 0.80 (HUI 2–HUI 3; musculoskeletal). Substantial differences in responsiveness were observed between measures.ConclusionsResults obtained with different preference-based quality-of-life measures in a sample of patients with mild to moderate disease severity are not equivalent. As differences between measures may have considerable effects in health economic evaluation studies, careful selection of instruments for a given study is essential.

KW - Health sciences

KW - Preference-based HRQoL

KW - Head-to-head comparison

KW - EQ-5D

KW - HUI 2

KW - HUI 3

KW - SF-6D

KW - 15D

KW - QWB-SA

UR - http://www.scopus.com/inward/record.url?scp=41149145533&partnerID=8YFLogxK

U2 - 10.1007/s11136-008-9317-6

DO - 10.1007/s11136-008-9317-6

M3 - Journal articles

AN - SCOPUS:41149145533

VL - 17

SP - 485

EP - 495

JO - Quality of Life Research

JF - Quality of Life Research

SN - 0962-9343

IS - 3

ER -