2D QSAR of PPARγ agonist binding and transactivation.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Authors

Multilinear QSAR models are developed for the largest and most diverse set of PPARγ agonists treated hitherto. Binding of these small molecules to the human nuclear receptor PPARγ is described by models that are built on simple 2D molecular descriptors and nevertheless are of good quality and predictive power (e.g., 144 compounds, 10 descriptors, r 2 = 0.79, r cv 2 = 0.76). The models presented are thoroughly validated by crossvalidation, randomization experiments, bootstrapping, and training set/test set partitioning. They may therefore be helpful in the design of new antidiabetic drug candidates. For gene transactivation, the functional activity of the agonists, a corresponding model for a similarly diverse compound set is of somewhat lower statistical quality.

OriginalspracheEnglisch
ZeitschriftBioorganic & Medicinal Chemistry
Jahrgang14
Ausgabenummer15
Seiten (von - bis)5178-5195
Anzahl der Seiten18
DOIs
PublikationsstatusErschienen - 01.08.2006
Extern publiziertJa

DOI

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