Tormentil for active ulcerative colitis: An Open-Label, Dose-Escalating Study

Research output: Journal contributionsJournal articlesResearchpeer-review

Authors

  • Roman Huber
  • Amelie von Ditfurth
  • Frank Amann
  • Corina Güthlin
  • Matthias Rostock
  • Rainer Trittler
  • Klaus Kümmerer
  • Irmgard Merfort

BACKGROUND: Tormentil extracts (TE) have antioxidative properties and are used as a complementary therapy for chronic inflammatory bowel disease. In individual patients with ulcerative colitis (UC) positive effects have been observed. GOALS: To assess the safety, pharmacology, and clinical effects of different doses of TE in patients with active UC. STUDY: Sixteen patients with active UC [clinical activity index (CAI) ≥5] received TE in escalating doses of 1200, 1800, 2400 and 3000 mg/d for 3 weeks each. Each treatment phase was followed by a 4-week washout phase. The outcome parameters were side effects, CAI, C-reactive protein, and tannin levels in patient sera. RESULTS: Mild upper abdominal discomfort was experienced by 6 patients (38%), but did not require discontinuation of the medication. During therapy with 2400 mg TE per day, median CAI and C-reactive protein improved from 8 (6 to 10.75) and 8 (3 to 17.75) mg/L at baseline to 4.5 (1.75 to 6) and 3 (3 to 6) mg/L, respectively. During therapy, the CAI decreased in all patients, whereas it increased during the washout phase. Neither undegraded nor metabolized tannins could be detected by liquid-mass spectrometry (LC-MS) in patient sera. CONCLUSIONS: TE appeared safe up to 3000 mg/d. Tannins from TE are not systemically absorbed. The efficacy in patients with UC should be further evaluated.

Original languageEnglish
JournalJournal of Clinical Gastroenterology
Volume41
Issue number9
Pages (from-to)834-838
Number of pages5
ISSN0192-0790
DOIs
Publication statusPublished - 01.10.2007
Externally publishedYes

    Research areas

  • Chemistry
  • CAI, Cohort study, Tannins, Ulcerative colitis

Recently viewed

Publications

  1. Composing with the terra fluida of interaction: new paths for CCO research as relational practice
  2. The 'need for speed'
  3. Introduction
  4. Exploring the Use of the Pronoun I in German Academic Texts with Machine Learning
  5. Information rigidities, inflation perceptions, and the media
  6. Inexistent Ink
  7. The pace of life for forest trees
  8. "Helden des Alltags"
  9. The hidden hand that shapes conceptual understanding: Choosing effective representations for teaching cell division and climate change
  10. Implementation of a balanced scorecard for hybrid business models
  11. Mapping and analysing historical indicators of ecosystem services in Germany
  12. Entrepreneurial actions
  13. Life-protecting neoliberalism
  14. Who likes to learn new things: measuring adult motivation to learn with PIAAC data from 21 countries
  15. Moving Around Myanmar
  16. The recent double paradigm shift in restoration ecology
  17. Moderators of intergroup evaluation in disadvantaged groups
  18. The bidirectional relationship between ESG performance and earnings management
  19. Computational Study of Three-Dimensional Lagrangian Transport and Mixing in a Stirred Tank Reactor  
  20. Insights into the accuracy of social scientists’ forecasts of societal change
  21. Legacy effects of land-use modulate tree growth responses to climate extremes
  22. Conception and analysis of Cascaded Dual Kalman Filters as virtual sensors for mastication activity of stomatognathic craniomandibular system
  23. Influence of Long-Lasting Static Stretching on Maximal Strength, Muscle Thickness and Flexibility
  24. The impact of digital innovation on path-dependent decision-making
  25. Misconceptions of Measurement Equivalence
  26. The Enduring Ephemeral, or the Future is a Memory.
  27. Corrosion behavior and microstructure of a broad range of Mg-Sn-X alloys
  28. The Impact of TV Ads on the Individual User's Purchasing Behavior
  29. Developments in Qualitative Mindfulness Practice Research
  30. Measuring at all scales: sourcing data for more flexible restoration references