The use of a monolithic column to improve the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, chlorpheniramine in pharmaceutical formulations by HPLC-A comparison with a conventional reversed-phase silica-based column

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@article{c2bd083bdfdb4ecdb3b105057b2d64a2,
title = "The use of a monolithic column to improve the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, chlorpheniramine in pharmaceutical formulations by HPLC-A comparison with a conventional reversed-phase silica-based column",
abstract = "A new simple, rapid, and sensitive liquid chromatographic method has been developed and validated for the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, and chlorpheniramine in pharmaceutical tablet formulations and was performed on conventional C 18 and monolithic silica C 18 columns. Chromatographic separation was achieved by using a mixture of methanol and a buffer containing 10mM NaH 2PO 4, 3mM heptane sulfonic acid sodium salt, 0.1% triethylamine, pH 2.5 (adjusted with hydrochloric acid) in a ratio 50:50v/v, 40:60v/v for conventional C 18 and monolithic silica C 18 columns, respectively. Quantitation was achieved with UV detection at 214nm, based on peak area. The proposed method could be used in the presence of salicylic acid as impurity or decomposition product in dosage forms containing aspirin. The proposed method was validated and successfully applied for the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing these multicomponent combinations.",
keywords = "Chemistry, chromatography, pharmaceuticals, COLUMN, monolithic, aspirin, caffeine, chlorpheniramine, dextromethorphan, paracetamol, pseudoephedrine, Sustainability Science",
author = "Hadad, {Ghada M.} and Mahmoud, {Waleed M. M.}",
year = "2011",
month = dec,
day = "1",
doi = "10.1080/10826076.2011.591031",
language = "English",
volume = "34",
pages = "2516–2532",
journal = "Journal of Liquid Chromatography and Related Technologies",
issn = "1082-6076",
publisher = "Taylor & Francis",
number = "20",

}

RIS

TY - JOUR

T1 - The use of a monolithic column to improve the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, chlorpheniramine in pharmaceutical formulations by HPLC-A comparison with a conventional reversed-phase silica-based column

AU - Hadad, Ghada M.

AU - Mahmoud, Waleed M. M.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - A new simple, rapid, and sensitive liquid chromatographic method has been developed and validated for the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, and chlorpheniramine in pharmaceutical tablet formulations and was performed on conventional C 18 and monolithic silica C 18 columns. Chromatographic separation was achieved by using a mixture of methanol and a buffer containing 10mM NaH 2PO 4, 3mM heptane sulfonic acid sodium salt, 0.1% triethylamine, pH 2.5 (adjusted with hydrochloric acid) in a ratio 50:50v/v, 40:60v/v for conventional C 18 and monolithic silica C 18 columns, respectively. Quantitation was achieved with UV detection at 214nm, based on peak area. The proposed method could be used in the presence of salicylic acid as impurity or decomposition product in dosage forms containing aspirin. The proposed method was validated and successfully applied for the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing these multicomponent combinations.

AB - A new simple, rapid, and sensitive liquid chromatographic method has been developed and validated for the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, and chlorpheniramine in pharmaceutical tablet formulations and was performed on conventional C 18 and monolithic silica C 18 columns. Chromatographic separation was achieved by using a mixture of methanol and a buffer containing 10mM NaH 2PO 4, 3mM heptane sulfonic acid sodium salt, 0.1% triethylamine, pH 2.5 (adjusted with hydrochloric acid) in a ratio 50:50v/v, 40:60v/v for conventional C 18 and monolithic silica C 18 columns, respectively. Quantitation was achieved with UV detection at 214nm, based on peak area. The proposed method could be used in the presence of salicylic acid as impurity or decomposition product in dosage forms containing aspirin. The proposed method was validated and successfully applied for the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing these multicomponent combinations.

KW - Chemistry

KW - chromatography

KW - pharmaceuticals

KW - COLUMN

KW - monolithic

KW - aspirin

KW - caffeine

KW - chlorpheniramine

KW - dextromethorphan

KW - paracetamol

KW - pseudoephedrine

KW - Sustainability Science

UR - http://www.scopus.com/inward/record.url?scp=84856257198&partnerID=8YFLogxK

U2 - 10.1080/10826076.2011.591031

DO - 10.1080/10826076.2011.591031

M3 - Journal articles

VL - 34

SP - 2516

EP - 2532

JO - Journal of Liquid Chromatography and Related Technologies

JF - Journal of Liquid Chromatography and Related Technologies

SN - 1082-6076

IS - 20

ER -