The concept of leverage points offers great potential to consider how we can intervene in systems to create transformations for sustainability. In this special issue, we draw together a diverse collection of research that engages with this central idea. The papers cover three broad topics: (1) the use of a ‘leverage points lens’ for systems framings and understandings; (2) how individual interventions can be understood and critiqued from a leverage points perspective; and (3) the implications of a leverage points approach for research practice and action. Across these topics, we present the papers, and embed them within current critical debate in sustainability science. In doing so, we produce nine guiding questions to shape the research and practice of leverage points for sustainability transformation. These nine questions introduce conceptual clarity to untangle some of the deeper questions around which system we are engaging with, whose system counts, and whose sustainability we are seeking to create. They further shape how we deliver a leverage points research practice. We intend, therefore, that our guiding questions open up exploration across systems and worldviews, and help us to dance with systems.