In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation

Research output: Journal contributionsJournal articlesResearchpeer-review

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In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation. / Tie, Di; Guan, Renguo; Liu, Huinan et al.

In: Journal of Magnesium and Alloys, Vol. 10, No. 6, 01.06.2022, p. 1631-1639.

Research output: Journal contributionsJournal articlesResearchpeer-review

Harvard

Tie, D, Guan, R, Liu, H, Chen, M, Ulasevich, SA, Skorb, EV, Holt-Torres, P, Lu, X & Hort, N 2022, 'In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation', Journal of Magnesium and Alloys, vol. 10, no. 6, pp. 1631-1639. https://doi.org/10.1016/j.jma.2020.11.005

APA

Vancouver

Tie D, Guan R, Liu H, Chen M, Ulasevich SA, Skorb EV et al. In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation. Journal of Magnesium and Alloys. 2022 Jun 1;10(6):1631-1639. Epub 2021 Jan 9. doi: 10.1016/j.jma.2020.11.005

Bibtex

@article{9d532f9d1d8a4cfcb90c4abd9fb171d9,
title = "In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation",
abstract = "The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades, among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial activity. Here, we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, which led to ca. 47% increase in ultimate tensile strength (from 195.0 MPa to 288.1 MPa) and more homogeneous degradation process compared with the untreated alloy. No post-interventional inflammation or pathological changes of the test animals were observed during the implantation period, and the corrosion rate (0.22 ± 0.04 mm·y−1) perfectly fitted the clinical ureteral stent indwelling time. The urine bacteria numbers decreased from 88 ± 13 CFU·mL−1 at 7 weeks post operation to 59 ± 8 CFU·mL−1 at 14 weeks post operation, which confirmed the evident antibacterial activity of the alloy. Our study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system, enabling its efficacious use as ureteral implant materials.",
keywords = "Biocompatibility, Biodegradability, In vivo, Mg–Zn–Sr alloy, Ureteral implant, Engineering",
author = "Di Tie and Renguo Guan and Huinan Liu and Minfang Chen and Ulasevich, {Sviatlana A.} and Skorb, {Ekaterina V.} and Patricia Holt-Torres and Xiaopeng Lu and Norbert Hort",
note = "Publisher Copyright: {\textcopyright} 2019",
year = "2022",
month = jun,
day = "1",
doi = "10.1016/j.jma.2020.11.005",
language = "English",
volume = "10",
pages = "1631--1639",
journal = "Journal of Magnesium and Alloys",
issn = "2213-9567",
publisher = "Chongqing University",
number = "6",

}

RIS

TY - JOUR

T1 - In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation

AU - Tie, Di

AU - Guan, Renguo

AU - Liu, Huinan

AU - Chen, Minfang

AU - Ulasevich, Sviatlana A.

AU - Skorb, Ekaterina V.

AU - Holt-Torres, Patricia

AU - Lu, Xiaopeng

AU - Hort, Norbert

N1 - Publisher Copyright: © 2019

PY - 2022/6/1

Y1 - 2022/6/1

N2 - The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades, among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial activity. Here, we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, which led to ca. 47% increase in ultimate tensile strength (from 195.0 MPa to 288.1 MPa) and more homogeneous degradation process compared with the untreated alloy. No post-interventional inflammation or pathological changes of the test animals were observed during the implantation period, and the corrosion rate (0.22 ± 0.04 mm·y−1) perfectly fitted the clinical ureteral stent indwelling time. The urine bacteria numbers decreased from 88 ± 13 CFU·mL−1 at 7 weeks post operation to 59 ± 8 CFU·mL−1 at 14 weeks post operation, which confirmed the evident antibacterial activity of the alloy. Our study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system, enabling its efficacious use as ureteral implant materials.

AB - The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades, among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial activity. Here, we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, which led to ca. 47% increase in ultimate tensile strength (from 195.0 MPa to 288.1 MPa) and more homogeneous degradation process compared with the untreated alloy. No post-interventional inflammation or pathological changes of the test animals were observed during the implantation period, and the corrosion rate (0.22 ± 0.04 mm·y−1) perfectly fitted the clinical ureteral stent indwelling time. The urine bacteria numbers decreased from 88 ± 13 CFU·mL−1 at 7 weeks post operation to 59 ± 8 CFU·mL−1 at 14 weeks post operation, which confirmed the evident antibacterial activity of the alloy. Our study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system, enabling its efficacious use as ureteral implant materials.

KW - Biocompatibility

KW - Biodegradability

KW - In vivo

KW - Mg–Zn–Sr alloy

KW - Ureteral implant

KW - Engineering

UR - http://www.scopus.com/inward/record.url?scp=85099250961&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/2c85707b-ae19-317c-99ab-4b35d0c5c91f/

U2 - 10.1016/j.jma.2020.11.005

DO - 10.1016/j.jma.2020.11.005

M3 - Journal articles

AN - SCOPUS:85099250961

VL - 10

SP - 1631

EP - 1639

JO - Journal of Magnesium and Alloys

JF - Journal of Magnesium and Alloys

SN - 2213-9567

IS - 6

ER -