1. //
  2. Start
  3. //
  4. Publications
  5. HPLC and chemometrics-assisted UV-spectr...
  6. Output formats
  7. //

HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule.

Research output: Journal contributions › Journal articles › Research

Standard

HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule. / Hadad, Ghada M.; El-Gindy, Alaa; Mahmoud, Waleed M. M.
In: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 70, No. 3, 01.08.2008, p. 655-663.

Research output: Journal contributions › Journal articles › Research

Harvard

Hadad, GM, El-Gindy, A & Mahmoud, WMM 2008, 'HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule.', Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 70, no. 3, pp. 655-663. https://doi.org/10.1016/j.saa.2007.08.016

APA

Hadad, G. M., El-Gindy, A., & Mahmoud, W. M. M. (2008). HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 70(3), 655-663. https://doi.org/10.1016/j.saa.2007.08.016

Vancouver

Hadad GM, El-Gindy A, Mahmoud WMM. HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2008 Aug 1;70(3):655-663. doi: 10.1016/j.saa.2007.08.016

Bibtex

@article{16e654d34759469d9667ea0d39eb7e62,
title = "HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule.",
abstract = "High-performance liquid chromatography (HPLC) and multivariate spectrophotometric methods are described for the simultaneous determination of ambroxol hydrochloride (AM) and doxycycline (DX) in combined pharmaceutical capsules. The chromatographic separation was achieved on reversed-phase C(18) analytical column with a mobile phase consisting of a mixture of 20mM potassium dihydrogen phosphate, pH 6-acetonitrile in ratio of (1:1, v/v) and UV detection at 245 nm. Also, the resolution has been accomplished by using numerical spectrophotometric methods as classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS-1) applied to the UV spectra of the mixture and graphical spectrophotometric method as first derivative of the ratio spectra ((1)DD) method. Analytical figures of merit (FOM), such as sensitivity, selectivity, analytical sensitivity, limit of quantitation and limit of detection were determined for CLS, PLS-1 and PCR methods. The proposed methods were validated and successfully applied for the analysis of pharmaceutical formulation and laboratory-prepared mixtures containing the two component combination. ",
keywords = "Chemistry, HPLC ANALYSIS, Ambroxol, Doxycyclin",
author = "Hadad, {Ghada M.} and Alaa El-Gindy and Mahmoud, {Waleed M. M.}",
year = "2008",
month = aug,
day = "1",
doi = "10.1016/j.saa.2007.08.016",
language = "English",
volume = "70",
pages = "655--663",
journal = "Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy",
issn = "1386-1425",
publisher = "Elsevier B.V.",
number = "3",

}

RIS

TY - JOUR

T1 - HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule.

AU - Hadad, Ghada M.

AU - El-Gindy, Alaa

AU - Mahmoud, Waleed M. M.

PY - 2008/8/1

Y1 - 2008/8/1

N2 - High-performance liquid chromatography (HPLC) and multivariate spectrophotometric methods are described for the simultaneous determination of ambroxol hydrochloride (AM) and doxycycline (DX) in combined pharmaceutical capsules. The chromatographic separation was achieved on reversed-phase C(18) analytical column with a mobile phase consisting of a mixture of 20mM potassium dihydrogen phosphate, pH 6-acetonitrile in ratio of (1:1, v/v) and UV detection at 245 nm. Also, the resolution has been accomplished by using numerical spectrophotometric methods as classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS-1) applied to the UV spectra of the mixture and graphical spectrophotometric method as first derivative of the ratio spectra ((1)DD) method. Analytical figures of merit (FOM), such as sensitivity, selectivity, analytical sensitivity, limit of quantitation and limit of detection were determined for CLS, PLS-1 and PCR methods. The proposed methods were validated and successfully applied for the analysis of pharmaceutical formulation and laboratory-prepared mixtures containing the two component combination.

AB - High-performance liquid chromatography (HPLC) and multivariate spectrophotometric methods are described for the simultaneous determination of ambroxol hydrochloride (AM) and doxycycline (DX) in combined pharmaceutical capsules. The chromatographic separation was achieved on reversed-phase C(18) analytical column with a mobile phase consisting of a mixture of 20mM potassium dihydrogen phosphate, pH 6-acetonitrile in ratio of (1:1, v/v) and UV detection at 245 nm. Also, the resolution has been accomplished by using numerical spectrophotometric methods as classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS-1) applied to the UV spectra of the mixture and graphical spectrophotometric method as first derivative of the ratio spectra ((1)DD) method. Analytical figures of merit (FOM), such as sensitivity, selectivity, analytical sensitivity, limit of quantitation and limit of detection were determined for CLS, PLS-1 and PCR methods. The proposed methods were validated and successfully applied for the analysis of pharmaceutical formulation and laboratory-prepared mixtures containing the two component combination.

KW - Chemistry

KW - HPLC ANALYSIS

KW - Ambroxol

KW - Doxycyclin

UR - http://www.scopus.com/inward/record.url?scp=44649142496&partnerID=8YFLogxK

U2 - 10.1016/j.saa.2007.08.016

DO - 10.1016/j.saa.2007.08.016

M3 - Journal articles

C2 - 17931962

VL - 70

SP - 655

EP - 663

JO - Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

SN - 1386-1425

IS - 3

ER -

DOI

Recently viewed

Projects

  1. Campus Virtuell

Activities

  1. Integration of a Heat Storage System into an Existing Household
  2. A Phenomenological Destruction of Ontology? Reiner Schürmann’s Reading of Marx and Heidegger
  3. The Public is Fine With Us: Idealized Value Mergers in Top Management
  4. Towards a New Aesthetic Paradigm
  5. Meaningful Classroom Music: A Blended Learning Approach
  6. ICSS Group (Externe Organisation)
  7. Organization Studies (Fachzeitschrift)
  8. Computational study of Lagrangian transport in turbulent convection
  9. “Assessing Representative Democracy, the Democratic Deficit and Institutional Reform
  10. Governance of Professional Service Firms: A Configurational Theory
  11. Between the Wage and the Commons
  12. Leverage Points in collaboration with artecology_network
  13. First Workshop on Applied Infrastructure Research 2004
  14. Reviewer in recruitment commission for external university

Publications

  1. Fast response of groundwater to heavy rainfall
  2. Progress and challenge for magnesium alloys as biomaterials
  3. Towards a Model for Building Trust and Acceptance of Artificial Intelligence Aided Medical Assessment Systems
  4. Conditionality of EU funds: an instrument to enforce EU fundamental values?
  5. The effect of complacency potential on human operators’ monitoring behavior in aviation
  6. Exploring fruitful links between real-world laboratory and disciplinary research Introduction of the DKN Future Earth working group LinkLab
  7. Potential bias in meta-analyses of effect sizes in imaging genetics
  8. Lernen in Netzwerken
  9. Introduction to Thinking the Problematic
  10. Understanding spam
  11. Nostalgia is not what it used to be
  12. Burdens, Stresses, Resources and Needs of School Management and Teaching staff during the Corona Pandemic. Results of a qualitative Interview Study at primary and secondary Schools in Hesse
  13. Generation of 3D representative volume elements for heterogeneous materials
  14. The challenges of gamifying CSR communication
  15. The conservation against development paradigm in protected areas
  16. Cross-level Information and Influence in Mandated Participatory Planning: Alternative Pathways to Sustainable Water Management in Germany’s Implementation of the EU Water Framework Directive
  17. “The whole is greater than the sum of its parts” – Exploring teachers’ technology readiness profiles and its relation to their emotional state during COVID-19 emergency remote teaching
  18. The Change Challenge
  19. A hybrid actuator modelling and hysteresis effect identification in camless internal combustion engines control
  20. Expanding the pie or spoiling the cake? How the number of negotiation issues affects integrative bargaining
  21. Be smart, play dumb? A transactional perspective on day-specific knowledge hiding, interpersonal conflict, and psychological strain
  22. Climate-smart socially innovative tools and approaches for marine pollution science in support of sustainable development
  23. Gehen in der Datenbank – Der BMLwalker
  24. Effect of Sn additions on the age hardening response, microstructures and corrosion resistance of Mg-0.8Ca (wt%) alloys
  25. Singularities and Superintelligence
  26. Evaluation of a temporal causal model for predicting the mood of clients in an online therapy
  27. Study Protocol
  28. The Effectivity of Technological Innovation on Mitigating the Costs of Climate Change Policies

Press / Media

  1. Too long, didn't read?