Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines

Research output: Journal contributionsJournal articlesResearchpeer-review

Authors

  • Frank Feyerabend
  • Janine Fischer
  • Jakob Holtz
  • Frank Witte
  • Regine Willumeit
  • Heiko Drücker
  • Carla Vogt
  • Norbert Hort

Degradable magnesium alloys for biomedical application are on the verge of being used clinically. Rare earth elements (REEs) are used to improve the mechanical properties of the alloys, but in more or less undefined mixtures. For some elements of this group, data on toxicity and influence on cells are sparse. Therefore in this study the in vitro cytotoxicity of the elements yttrium (Y), neodymium (Nd), dysprosium (Dy), praseodymium (Pr), gadolinium (Gd), lanthanum (La), cerium (Ce), europium (Eu), lithium (Li) and zirconium (Zr) was evaluated by incubation with the chlorides (10-2000 μM); magnesium (Mg) and calcium (Ca) were tested at higher concentrations (200 and 50 mM, respectively). The influence on viability of human osteosarcoma cell line MG63, human umbilical cord perivascular (HUCPV) cells and mouse macrophages (RAW 264.7) was determined, as well as the induction of apoptosis and the expression of inflammatory factors (TNF-α, IL-1α). Significant differences between the applied cells could be observed. RAW exhibited the highest and HUCPV the lowest sensitivity. La and Ce showed the highest cytotoxicity of the analysed elements. Of the elements with high solubility in magnesium alloys, Gd and Dy seem to be more suitable than Y. The focus of magnesium alloy development for biomedical applications should include most defined alloy compositions with well-known tissue-specific and systemic effects.

Original languageEnglish
JournalActa Biomaterialia
Volume6
Issue number5
Pages (from-to)1834-1842
Number of pages9
ISSN1742-7061
DOIs
Publication statusPublished - 05.2010
Externally publishedYes

    Research areas

  • In vitro, Inflammatory response, Magnesium, Rare earth elements, Toxicity
  • Engineering

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