TY - JOUR

T1 - Blood triggered corrosion of magnesium alloys

AU - Geis-Gerstorfer, J.

AU - Schille, Ch

AU - Schweizer, E.

AU - Rupp, F.

AU - Scheideler, L.

AU - Reichel, H. P.

AU - Hort, N.

AU - Nolte, A.

AU - Wendel, H. P.

PY - 2011/12/15

Y1 - 2011/12/15

N2 - Intravascular stents manufactured out of bioabsorbable magnesium (Mg) or Mg-alloys are considered as auspicious candidates for the next stent generation. However, before clinical application numerous physical and biological tests, especially to predict the clinically highly important degradation kinetics in vivo, have to be performed. In a Chandler-Loop model, the initial degradation of eight different magnesium alloys during 6 h in contact with human whole blood was investigated. The magnesium release varied between 0.91 ± 0.33 mg/cm2 (MgAl9Zn1) and 2.57 ± 0.38 mg/cm2 (MgZn1). No correlation could be found with Mg release data obtained after immersion in simulated body fluid (SBF). This pilot study showed that Mg corrosion is highly influenced by the biological test environment (SBF or blood, etc.) and that a modified Chandler-Loop model with human whole blood may be superior to predict corrosion of Mg alloys under clinical conditions than the SBF models presently used.

AB - Intravascular stents manufactured out of bioabsorbable magnesium (Mg) or Mg-alloys are considered as auspicious candidates for the next stent generation. However, before clinical application numerous physical and biological tests, especially to predict the clinically highly important degradation kinetics in vivo, have to be performed. In a Chandler-Loop model, the initial degradation of eight different magnesium alloys during 6 h in contact with human whole blood was investigated. The magnesium release varied between 0.91 ± 0.33 mg/cm2 (MgAl9Zn1) and 2.57 ± 0.38 mg/cm2 (MgZn1). No correlation could be found with Mg release data obtained after immersion in simulated body fluid (SBF). This pilot study showed that Mg corrosion is highly influenced by the biological test environment (SBF or blood, etc.) and that a modified Chandler-Loop model with human whole blood may be superior to predict corrosion of Mg alloys under clinical conditions than the SBF models presently used.

KW - Blood corrosion

KW - Chandler-Loop

KW - Mg release

KW - Simulated body fluid (SBF)

KW - Static immersion test

KW - Stent

KW - Engineering

UR - http://www.scopus.com/inward/record.url?scp=80255129737&partnerID=8YFLogxK

U2 - 10.1016/j.mseb.2011.06.006

DO - 10.1016/j.mseb.2011.06.006

M3 - Journal articles

AN - SCOPUS:80255129737

VL - 176

SP - 1761

EP - 1766

JO - Materials Science and Engineering: B

JF - Materials Science and Engineering: B

SN - 0921-5107

IS - 20

ER -