Antidepressants: relationship to the time to psychiatric readmission and probability of being in hospital in depressive patients
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In: Frontiers in Public Health, Vol. 2, No. May, 40, 08.05.2014.
Research output: Journal contributions › Journal articles › Research › peer-review
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TY - JOUR
T1 - Antidepressants
T2 - relationship to the time to psychiatric readmission and probability of being in hospital in depressive patients
AU - Warnke, Ingeborg
AU - Nordt, Carlos
AU - Moock, Jörn
AU - Kawohl, Wolfram
AU - Rössler, Wulf
PY - 2014/5/8
Y1 - 2014/5/8
N2 - Introduction: Although antidepressants play a major role in the treatment of patients with depression, it is unclear which specific antidepressants are more efficacious than others. This study aims to analyze the relationship between several antidepressant substances and the time to readmission as well as the probability of being in hospital in a given week by using prescription data. Methods: The database was health-insurance claim data from the new Federal States in Germany. The analysis consisted of all patients with unipolar depression at their index admission in 2007 (N D1803). Patients were followed up for 2 years after discharge from index hospitalization. Statistical analyses were conducted by discrete-time hazards models and general estimation equation models, accounting for various predictors. Results: Of all prescribed antidepressant substances, sertralinewas related to an increased time to readmission by 37% and to a reduction in the probability of being in hospital in a given week by 40%. However, it was prescribed to only about 5% of the patients. Conclusion: In this study, only sertraline appeared to have clinical and economic advantages. It is remarkable that just a minority of patients received sertraline in our study, thus differing from the prescription pattern in the US.
AB - Introduction: Although antidepressants play a major role in the treatment of patients with depression, it is unclear which specific antidepressants are more efficacious than others. This study aims to analyze the relationship between several antidepressant substances and the time to readmission as well as the probability of being in hospital in a given week by using prescription data. Methods: The database was health-insurance claim data from the new Federal States in Germany. The analysis consisted of all patients with unipolar depression at their index admission in 2007 (N D1803). Patients were followed up for 2 years after discharge from index hospitalization. Statistical analyses were conducted by discrete-time hazards models and general estimation equation models, accounting for various predictors. Results: Of all prescribed antidepressant substances, sertralinewas related to an increased time to readmission by 37% and to a reduction in the probability of being in hospital in a given week by 40%. However, it was prescribed to only about 5% of the patients. Conclusion: In this study, only sertraline appeared to have clinical and economic advantages. It is remarkable that just a minority of patients received sertraline in our study, thus differing from the prescription pattern in the US.
KW - Psychology
KW - antidepressants
KW - depression
KW - sertraline
KW - time to psychiatric readmission
KW - time hazard models
UR - http://www.scopus.com/inward/record.url?scp=85018525685&partnerID=8YFLogxK
U2 - 10.3389/fpubh.2014.00040
DO - 10.3389/fpubh.2014.00040
M3 - Journal articles
C2 - 24847477
VL - 2
JO - Frontiers in Public Health
JF - Frontiers in Public Health
SN - 2296-2565
IS - May
M1 - 40
ER -