Age- and gender-specific mortality risk profiles for depressive outpatients with major chronic medical diseases

Research output: Journal contributionsJournal articlesResearch

Standard

Age- and gender-specific mortality risk profiles for depressive outpatients with major chronic medical diseases. / Warnke, Ingeborg; Nordt, Carlos; Kawohl, Wolfram et al.

In: Journal of Affective Disorders, Vol. 193, No. 15.03.2016, 15.03.2016, p. 295-304.

Research output: Journal contributionsJournal articlesResearch

Harvard

APA

Vancouver

Bibtex

@article{0dfe01df4ea34362affaacfd9f9715cb,
title = "Age- and gender-specific mortality risk profiles for depressive outpatients with major chronic medical diseases",
abstract = "BACKGROUND: As leading causes of death, chronic medical diseases, particularly common cardiovascular diseases, are associated with depression. The combination of depression and chronic medical disease in turn is linked with poorer health and premature death. Despite numerous studies on mortality in people with depression and chronic medical disease, the effects of age and gender were not consistently considered. To appropriately estimate mortality in the clinical setting, we aimed to analyse age- and gender-specific mortality profiles in outpatients with depression and chronic medical disease by considering depression severity.METHODS: We examined data from N=327,018 outpatients with depression aged 18 years and older (mean=60 years), which we obtained from German electronic health-insurance claims data covering the years 2007-2010. We considered major chronic medical disease groups: cardiovascular diseases, diabetes, diseases of the respiratory system and cancer. To analyse both adjusted mortality risk and rates over one year in a comprehensive manner, we calculated General Estimation Equation (GEE) Poisson models for binary data.RESULTS: The mortality risk increased with age and was higher for males. Especially patients below 60 years of age with cancer or diabetes had an increased mortality risk, but not patients with cardiovascular disease. Mortality was comparably increased in patients with severe depression, diabetes or respiratory disease.LIMITATIONS: We did not have data from a control group without depression.CONCLUSIONS: Notably, not cardiovascular diseases but cancer and, to a lesser extent, diabetes, both in younger patients, respiratory diseases and severity of depression require particular attention in outpatient care to reduce mortality.",
keywords = "Health sciences, Depression, Chronic medical disease, Mortality risk, Mortality rate, Age, Gender",
author = "Ingeborg Warnke and Carlos Nordt and Wolfram Kawohl and J{\"o}rn Moock and Wulf R{\"o}ssler",
note = "Copyright {\textcopyright} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
month = mar,
day = "15",
doi = "10.1016/j.jad.2016.01.006",
language = "English",
volume = "193",
pages = "295--304",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier B.V.",
number = "15.03.2016",

}

RIS

TY - JOUR

T1 - Age- and gender-specific mortality risk profiles for depressive outpatients with major chronic medical diseases

AU - Warnke, Ingeborg

AU - Nordt, Carlos

AU - Kawohl, Wolfram

AU - Moock, Jörn

AU - Rössler, Wulf

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016/3/15

Y1 - 2016/3/15

N2 - BACKGROUND: As leading causes of death, chronic medical diseases, particularly common cardiovascular diseases, are associated with depression. The combination of depression and chronic medical disease in turn is linked with poorer health and premature death. Despite numerous studies on mortality in people with depression and chronic medical disease, the effects of age and gender were not consistently considered. To appropriately estimate mortality in the clinical setting, we aimed to analyse age- and gender-specific mortality profiles in outpatients with depression and chronic medical disease by considering depression severity.METHODS: We examined data from N=327,018 outpatients with depression aged 18 years and older (mean=60 years), which we obtained from German electronic health-insurance claims data covering the years 2007-2010. We considered major chronic medical disease groups: cardiovascular diseases, diabetes, diseases of the respiratory system and cancer. To analyse both adjusted mortality risk and rates over one year in a comprehensive manner, we calculated General Estimation Equation (GEE) Poisson models for binary data.RESULTS: The mortality risk increased with age and was higher for males. Especially patients below 60 years of age with cancer or diabetes had an increased mortality risk, but not patients with cardiovascular disease. Mortality was comparably increased in patients with severe depression, diabetes or respiratory disease.LIMITATIONS: We did not have data from a control group without depression.CONCLUSIONS: Notably, not cardiovascular diseases but cancer and, to a lesser extent, diabetes, both in younger patients, respiratory diseases and severity of depression require particular attention in outpatient care to reduce mortality.

AB - BACKGROUND: As leading causes of death, chronic medical diseases, particularly common cardiovascular diseases, are associated with depression. The combination of depression and chronic medical disease in turn is linked with poorer health and premature death. Despite numerous studies on mortality in people with depression and chronic medical disease, the effects of age and gender were not consistently considered. To appropriately estimate mortality in the clinical setting, we aimed to analyse age- and gender-specific mortality profiles in outpatients with depression and chronic medical disease by considering depression severity.METHODS: We examined data from N=327,018 outpatients with depression aged 18 years and older (mean=60 years), which we obtained from German electronic health-insurance claims data covering the years 2007-2010. We considered major chronic medical disease groups: cardiovascular diseases, diabetes, diseases of the respiratory system and cancer. To analyse both adjusted mortality risk and rates over one year in a comprehensive manner, we calculated General Estimation Equation (GEE) Poisson models for binary data.RESULTS: The mortality risk increased with age and was higher for males. Especially patients below 60 years of age with cancer or diabetes had an increased mortality risk, but not patients with cardiovascular disease. Mortality was comparably increased in patients with severe depression, diabetes or respiratory disease.LIMITATIONS: We did not have data from a control group without depression.CONCLUSIONS: Notably, not cardiovascular diseases but cancer and, to a lesser extent, diabetes, both in younger patients, respiratory diseases and severity of depression require particular attention in outpatient care to reduce mortality.

KW - Health sciences

KW - Depression

KW - Chronic medical disease

KW - Mortality risk

KW - Mortality rate

KW - Age

KW - Gender

UR - http://www.sciencedirect.com/science/article/pii/S0165032715306546

U2 - 10.1016/j.jad.2016.01.006

DO - 10.1016/j.jad.2016.01.006

M3 - Journal articles

C2 - 26774517

VL - 193

SP - 295

EP - 304

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 15.03.2016

ER -