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A potassium channel protein encoded by chlorella virus PBCV-1

Research output: Journal contributions › Journal articles › Research › peer-review

Standard

A potassium channel protein encoded by chlorella virus PBCV-1. / Plugge, Barbara; Gazzarrini, Sabrina; Nelson, Michael C. et al.

In: Science, Vol. 287, No. 5458, 03.03.2000, p. 1641-1644.

Research output: Journal contributions › Journal articles › Research › peer-review

Harvard

Plugge, B, Gazzarrini, S, Nelson, MC, Cerana, R, Van Etten, JL, Derst, C, DiFrancesco, D, Moroni, A & Thiel, G 2000, 'A potassium channel protein encoded by chlorella virus PBCV-1', Science, vol. 287, no. 5458, pp. 1641-1644. https://doi.org/10.1126/science.287.5458.1641

APA

Plugge, B., Gazzarrini, S., Nelson, M. C., Cerana, R., Van Etten, J. L., Derst, C., DiFrancesco, D., Moroni, A., & Thiel, G. (2000). A potassium channel protein encoded by chlorella virus PBCV-1. Science, 287(5458), 1641-1644. https://doi.org/10.1126/science.287.5458.1641

Vancouver

Plugge B, Gazzarrini S, Nelson MC, Cerana R, Van Etten JL, Derst C et al. A potassium channel protein encoded by chlorella virus PBCV-1. Science. 2000 Mar 3;287(5458):1641-1644. doi: 10.1126/science.287.5458.1641

Bibtex

@article{7ab8a122732940a6bff14022595902f3,
title = "A potassium channel protein encoded by chlorella virus PBCV-1",
abstract = "The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the signature sequence of the pore domain of potassium channel proteins. Phylogenetic analyses of the encoded protein, Kcv, indicate a previously unidentified type of potassium channel. The messenger RNA encoded by the ORF leads to functional expression of a potassium-selective conductance in Xenopus laevis oocytes. The channel blockers amantadine and barium, but not cesium, inhibit this conductance, in addition to virus plaque formation. Thus, PBCV-1 encodes the first known viral protein that functions as a potassium-selective channel and is essential in the virus life cycle.",
keywords = "Biology",
author = "Barbara Plugge and Sabrina Gazzarrini and Nelson, {Michael C.} and Raffaella Cerana and {Van Etten}, {James L.} and Christian Derst and Dario DiFrancesco and A Moroni and Gerhard Thiel",
year = "2000",
month = mar,
day = "3",
doi = "10.1126/science.287.5458.1641",
language = "English",
volume = "287",
pages = "1641--1644",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science (AAAS)",
number = "5458",

}

RIS

TY - JOUR

T1 - A potassium channel protein encoded by chlorella virus PBCV-1

AU - Plugge, Barbara

AU - Gazzarrini, Sabrina

AU - Nelson, Michael C.

AU - Cerana, Raffaella

AU - Van Etten, James L.

AU - Derst, Christian

AU - DiFrancesco, Dario

AU - Moroni, A

AU - Thiel, Gerhard

PY - 2000/3/3

Y1 - 2000/3/3

N2 - The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the signature sequence of the pore domain of potassium channel proteins. Phylogenetic analyses of the encoded protein, Kcv, indicate a previously unidentified type of potassium channel. The messenger RNA encoded by the ORF leads to functional expression of a potassium-selective conductance in Xenopus laevis oocytes. The channel blockers amantadine and barium, but not cesium, inhibit this conductance, in addition to virus plaque formation. Thus, PBCV-1 encodes the first known viral protein that functions as a potassium-selective channel and is essential in the virus life cycle.

AB - The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the signature sequence of the pore domain of potassium channel proteins. Phylogenetic analyses of the encoded protein, Kcv, indicate a previously unidentified type of potassium channel. The messenger RNA encoded by the ORF leads to functional expression of a potassium-selective conductance in Xenopus laevis oocytes. The channel blockers amantadine and barium, but not cesium, inhibit this conductance, in addition to virus plaque formation. Thus, PBCV-1 encodes the first known viral protein that functions as a potassium-selective channel and is essential in the virus life cycle.

KW - Biology

UR - http://www.scopus.com/inward/record.url?scp=0034008733&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/1d5e3004-efbf-328f-bd16-ee969147261e/

U2 - 10.1126/science.287.5458.1641

DO - 10.1126/science.287.5458.1641

M3 - Journal articles

C2 - 10698737

VL - 287

SP - 1641

EP - 1644

JO - Science

JF - Science

SN - 0036-8075

IS - 5458

ER -

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