Securing individual well-being represents an important societal goal. While governments across the world have introduced multiple initiatives to ensure and promote mental health, support for vulnerable population groups remains insufficient, highlighting the need for innovative approaches. Digital technologies offer the potential to enhance well-being. At the same time, their use can also result in numerous (unintended) risks. To enrich and stimulate scientific discourse in this area, this special issue presents five interdisciplinary contributions positioned at the intersection of digital technology use and users’ well-being. Topics include the effects of addictive design and dark patterns, the supportive role of online mental health communities, measuring eudaimonic virtues in technology interaction, gendered experiences and strategies for managing technostress at work, and dynamic practices of digital disconnection. Together, these papers contribute to a better understanding of the complexities behind technology use, provide a foundation for policy development, and aim to enhance societal awareness of how digital tools can shape users’ mental health and overall well-being.