TY - JOUR

T1 - Time course of exhaled hydrogen peroxide and nitric oxide during chemotherapy

AU - Wewel, A. R.

AU - Crusius, J. A. M.

AU - Gatzemeier, U

AU - Heckmayr, M

AU - Becher, G

AU - Magnussen, H

AU - Jorres, R. A.

AU - Holz, O

PY - 2006/5/1

Y1 - 2006/5/1

N2 - This study was designed to assess the effect of differential leukocyte depletion during chemotherapy by monitoring the levels of exhaled hydrogen peroxide H 2O 2 and nitric oxide (FeNO) present. In 39 patients with lung cancer (chronic obstructive pulmonary disorder up to stage II, median forced expiratory volume in one second 78% predicted), measurements were performed before a cycle of therapy (day 1), at least once during the cycle (day 8: n=34; day 15: n=19), and afterwards (days 21-29). There were significant changes in the level of H 2O 2, FeNo and peripheral blood cell differentials over the visits. The level of H 2O 2 was decreased only on day 15, with a median (difference between the upper and lower quartiles) fall of 31 (57)%, while FeNO was reduced only on day 8, by 22 (40)%. Neutrophil numbers were unchanged on day 8 and decreased by 59 (48)% on day 15, while monocyte numbers were decreased on day 8 by 87 (39)%. On days 21-29, values had returned to baseline. Taken together with previous findings, the parallel course of levels of exhaled hydrogen peroxide and neutrophil counts suggests that a major part of exhaled hydrogen peroxide is due to neutrophils via the conducting airways. In contrast, the production of exhaled nitric oxide seems to be primarily associated with monocytes.

AB - This study was designed to assess the effect of differential leukocyte depletion during chemotherapy by monitoring the levels of exhaled hydrogen peroxide H 2O 2 and nitric oxide (FeNO) present. In 39 patients with lung cancer (chronic obstructive pulmonary disorder up to stage II, median forced expiratory volume in one second 78% predicted), measurements were performed before a cycle of therapy (day 1), at least once during the cycle (day 8: n=34; day 15: n=19), and afterwards (days 21-29). There were significant changes in the level of H 2O 2, FeNo and peripheral blood cell differentials over the visits. The level of H 2O 2 was decreased only on day 15, with a median (difference between the upper and lower quartiles) fall of 31 (57)%, while FeNO was reduced only on day 8, by 22 (40)%. Neutrophil numbers were unchanged on day 8 and decreased by 59 (48)% on day 15, while monocyte numbers were decreased on day 8 by 87 (39)%. On days 21-29, values had returned to baseline. Taken together with previous findings, the parallel course of levels of exhaled hydrogen peroxide and neutrophil counts suggests that a major part of exhaled hydrogen peroxide is due to neutrophils via the conducting airways. In contrast, the production of exhaled nitric oxide seems to be primarily associated with monocytes.

KW - Biology

KW - Carboplatin

KW - Cisplatin

KW - exhaled breath condensate

KW - neutrophils

KW - peripheral blood

UR - http://www.scopus.com/inward/record.url?scp=33845502489&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/642386b0-aea1-3191-97c5-b37b9cfc9e55/

U2 - 10.1183/09031936.06.00101705

DO - 10.1183/09031936.06.00101705

M3 - Journal articles

C2 - 16707398

VL - 27

SP - 1033

EP - 1039

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 5

ER -