The use of a monolithic column to improve the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, chlorpheniramine in pharmaceutical formulations by HPLC-A comparison with a conventional reversed-phase silica-based column

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Authors

  • Ghada M. Hadad
  • Waleed M. M. Mahmoud
A new simple, rapid, and sensitive liquid chromatographic method has been developed and validated for the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, and chlorpheniramine in pharmaceutical tablet formulations and was performed on conventional C 18 and monolithic silica C 18 columns. Chromatographic separation was achieved by using a mixture of methanol and a buffer containing 10mM NaH 2PO 4, 3mM heptane sulfonic acid sodium salt, 0.1% triethylamine, pH 2.5 (adjusted with hydrochloric acid) in a ratio 50:50v/v, 40:60v/v for conventional C 18 and monolithic silica C 18 columns, respectively. Quantitation was achieved with UV detection at 214nm, based on peak area. The proposed method could be used in the presence of salicylic acid as impurity or decomposition product in dosage forms containing aspirin. The proposed method was validated and successfully applied for the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing these multicomponent combinations.
Titel in ÜbersetzungDer Gebrauch einer monolithischen Säule zur verbesserten simultanen Bestimmung von Koffein, Paracetamol, Pseudoephedrin, Aspirin, Dextromethorphan und Chlorphentramin in pharmazeutischen Formulierungen mittels HPLC - Vergleich mit einer konmventionellen RP-Säule auf Silikabasis
OriginalspracheEnglisch
ZeitschriftJournal of Liquid Chromatography and Related Technologies
Jahrgang34
Ausgabenummer20
Seiten (von - bis)2516–2532
Anzahl der Seiten17
ISSN1082-6076
DOIs
PublikationsstatusErschienen - 01.12.2011

DOI

Zuletzt angesehen

Publikationen

  1. Serendipity as a Mechanism of Change and its Potential for Explaining Change Processes
  2. Investigations on hot tearing of Mg-Al binary alloys by using a new quantitative method
  3. Digital Transformation and Institutional Work: A Paradox View
  4. The Crowd in Flux
  5. Representation of Integration Profiles Using an Ontology
  6. Analysing Positional Data
  7. RAWSim-O: A Simulation Framework for Robotic Mobile Fulfillment Systems
  8. Nonlinear analyses of self-paced reading
  9. Perception of Space and Time in a Created Environment
  10. Usage pattern-based exposure screening as a simple tool for the regional priority-setting in environmental risk assessment of veterinary antibiotics
  11. Diffusion of the Balanced Scorecard
  12. Implementation of formative assessment
  13. A Theory-Based Teaching Concept To Embed Sustainability In The Engineering Curriculum
  14. Import and export of ideas
  15. Horizontal, but not vertical canopy structure is related to stand functional diversity in a subtropical slope forest
  16. State-wide university implementation of an online platform for eating disorders screening and intervention.
  17. Effect of yttrium addition on lattice parameter, Young's modulus and vacancy of magnesium
  18. Studying embodied encounters
  19. Connected Text Reading and Differences in Text Reading Fluency in Adult Readers
  20. Anisotropic wavelet bases and restricted nonlinear approximation
  21. Determinants of mandatory goodwill disclosure
  22. From Enterprise Architecture to Business Ecosystem Architecture
  23. A new method for collecting agile tiger beetles by live pitfall trapping
  24. A Person-Centered Approach for Analyzing Multidimensional Integration in Collaboration Between Educational Researchers and Practitioners