Simultaneous Determination of 11 Sulfonamides by HPLC–UV and Application for Fast Screening of Their Aerobic Elimination and Biodegradation in a Simple Test

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Authors

Sulfonamides (SAs) are one of the most frequently used antibiotics. SAs have been found in various environmental compartments. If SAs are not degraded in the environment, they can affect bacteria by their antibiotic properties and contribute to bacterial antibiotic resistance. Therefore, the biodegradability of 11 SAs (sulfanilamide, sulfaguanidine monohydrate, sulfadiazine, sulfathiazole, sulfapyridine, sulfamerazine, sulfamethoxypyridazine, sulfachloropyridazine, sulfamethazine, sulfamethoxazole, and sulfadimethoxine) was studied. For this purpose, the Closed Bottle Test (CBT, OECD 301D) was performed, which includes a toxicity control. In order to monitor the environmental fate of the parent compound and to check for transformation products, a simple, efficient, and reliable HPLC-UV method for the simultaneous determination of these SAs has been developed. Acetonitrile and water (with 0.1% formic acid) were used as mobile phase solvents for gradient elution. The method was validated in terms of precision, detection and quantitation limits, selectivity, and analytical solution stability. In the CBT, none of these SAs was readily biodegradable. The HPLC-UV analysis confirmed that no degradation of any SA took place. In the toxicity control, these SAs showed no toxic effect in the used concentration of environmental bacteria applied in the test.

OriginalspracheEnglisch
ZeitschriftClean - Soil, Air, Water
Jahrgang41
Ausgabenummer9
Seiten (von - bis)907-916
Anzahl der Seiten10
DOIs
PublikationsstatusErschienen - 09.2013

Zugehörige Projekte

  • Verringerung des Eintrags an Tierarzneimitteln in die Umwelt mit besser abbaubaren Sulfonamiden

    Projekt: Forschung

DOI

Zuletzt angesehen

Publikationen

  1. Social identity and place-based dynamics in community resilience building for natural disasters
  2. Parameters, concepts and the terminology of outer space law: a review of the essential facilities served by outer space activities and the rules of interpretation for treaty law and soft law guidelines.
  3. How to serve sustainability performance in businesses?
  4. Can radicals get a seat on the negotiation table? A Dynamic Perspective on Legitimation Processes.
  5. DeFacto - Temporal and multilingual deep fact validation
  6. Registered Replication Report on Srull and Wyer (1979)
  7. A Global Synthesis of Jatropha Cultivation
  8. Managing increasing environmental risks through agro-biodiversity and agri-environmental policies
  9. The effects of an active development of the mental model in the training process
  10. Recycling-oriented fabrication of soft robots
  11. Can Pulsed Electric Fields Treated Algal Cells Be Used as Stationary Phase in Chromatography?
  12. Unpacking the Personal Initiative-Performance Relationship
  13. The ten principles of green sample preparation
  14. Christian Steinbacher
  15. Calibration of the Chemcatcher ® passive sampler for monitoring selected polar and semi-polar pesticides in surface water
  16. Uncovering Divergence
  17. The continued relevance of compromissory clauses as a source of ICJ jurisdiction
  18. Exploring the Poincaré Ellipsis
  19. Taboo metaphtonymy, gender, and impoliteness
  20. The aftermath of colonization and forms of transactions between agriculture and industry - Exchange relations between industrialized and developing countries in the world economy of tobacco
  21. Managing uncertainty in the marketing of new-technology products
  22. Genau wahrnehmen - differenziert fördern
  23. Materialität der Diagramme
  24. Assessment of the biotic and abiotic elimination processes of five micropollutants during cultivation of the green microalgae Acutodesmus obliquus
  25. 'Creativity and Innovation' in the Nineteenth Century
  26. The relationship between working alliance and client outcomes in coaching