Seasonal allergic rhinitis and antihistamine effects on children's learning
Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet
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in: Annals of Allergy, Jahrgang 71, Nr. 2, 08.1993, S. 121-126.
Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet
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TY - JOUR
T1 - Seasonal allergic rhinitis and antihistamine effects on children's learning
AU - Vuurman, E. F.P.M.
AU - Van Veggel, L. M.A.
AU - Uiterwijk, M. M.C.
AU - Leutner, Detlev
AU - O'Hanlon, J. F.
PY - 1993/8
Y1 - 1993/8
N2 - Children suffering from seasonal allergic rhinitis and matched normals were instructed on the use of a didactic computer simulation in a realistic classroom situation. Groups of atopic children received different treatments before instruction; ie, sedating (diphenhydramine HCl) or nonsedating (loratadine) antihistamines or placebo. All returned after 2 weeks for an examination measuring factual and conceptual knowledge and the application of a learned strategy. Examination results showed large and consistent impairing effects of the allergic reaction on prior learning. Both the placebo and diphenhydramine groups learned significantly less than normal controls. The loratadine group's learning performance was superior to either of the other atopic groups' but still inferior to the normals'. Our conclusions are that the allergic reaction reduces learning ability in children and that this effect is partially counteracted by treatment with loratadine and aggravated by diphenhydramine.
AB - Children suffering from seasonal allergic rhinitis and matched normals were instructed on the use of a didactic computer simulation in a realistic classroom situation. Groups of atopic children received different treatments before instruction; ie, sedating (diphenhydramine HCl) or nonsedating (loratadine) antihistamines or placebo. All returned after 2 weeks for an examination measuring factual and conceptual knowledge and the application of a learned strategy. Examination results showed large and consistent impairing effects of the allergic reaction on prior learning. Both the placebo and diphenhydramine groups learned significantly less than normal controls. The loratadine group's learning performance was superior to either of the other atopic groups' but still inferior to the normals'. Our conclusions are that the allergic reaction reduces learning ability in children and that this effect is partially counteracted by treatment with loratadine and aggravated by diphenhydramine.
KW - Psychology
KW - Child
KW - Cognition
KW - Diphenhydramine/adverse effects
KW - Female
KW - Humans
KW - Hypersensitivity, Immediate/drug therapy
KW - Learning/drug effects
KW - Loratadine/adverse effects
KW - Male
KW - Rhinitis, Allergic, Seasonal/drug therapy
UR - http://www.scopus.com/inward/record.url?scp=0027194790&partnerID=8YFLogxK
U2 - 10.1016/0924-977X(92)90101-D
DO - 10.1016/0924-977X(92)90101-D
M3 - Journal articles
C2 - 8346863
AN - SCOPUS:0027194790
VL - 71
SP - 121
EP - 126
JO - Annals of Allergy
JF - Annals of Allergy
SN - 0003-4738
IS - 2
ER -