The ego depletion effect posits that initial exertion of self-control impairs subsequent self-regulatory performance. Despite being examined in over 1000 independent studies and cited extensively, recent large-scale studies have questioned its validity. We propose that the replicability of ego depletion may hinge on the intensity of the manipulation. Our new paradigm, involving a demanding antisaccade task lasting for 30–40 min followed by a Go-Nogo task, was tested across 14 samples, totaling 2078 participants worldwide, both in laboratory settings and online. Results consistently demonstrated significant ego depletion effects (d = 0.31 to 0.35) with minimal heterogeneity (I² = 0). Bayesian meta-analysis further supported these findings with strong evidence (BF₁₀ > 700). This study underscores the importance of manipulation intensity in ego depletion research and provides a reliable method for future studies. These findings have significant implications for resolving empirical controversies in ego depletion and addressing the broader replication crisis in psychology.