Interfacing medicinal chemistry with structural bioinformatics: implications for T box riboswitch RNA drug discovery

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Authors

  • Franziska Jentzsch
  • Jennifer V Hines

The T box riboswitch controls bacterial transcription by structurally responding to tRNA aminoacylation charging ratios. Knowledge of the thermodynamic stability difference between two competing structural elements within the riboswitch, the terminator and the antiterminator, is critical for effective T box-targeted drug discovery. The ΔG of aminoacyl tRNA synthetase (aaRS) T box riboswitch terminators and antiterminators was predicted using DINAMelt and the resulting ΔΔG (ΔG Terminator - ΔG Antiterminator) values were compared. Average ΔΔG values did not differ significantly between the bacterial species analyzed, but there were significant differences based on the type of aaRS. The data indicate that, of the bacteria studied, there is little potential for drug targeting based on overall bacteria-specific thermodynamic differences of the T box antiterminator vs. terminator stability, but that aaRS-specific thermodynamic differences could possibly be exploited for designing drug specificity.

OriginalspracheEnglisch
AufsatznummerS5
ZeitschriftBMC Bioinformatics
Jahrgang13 Suppl 2
AusgabenummerSuppl 2
Seiten (von - bis)1-5
Anzahl der Seiten5
ISSN1471-2105
DOIs
PublikationsstatusErschienen - 13.03.2012

Dokumente

Links

DOI

Zuletzt angesehen

Publikationen

  1. Modelling the first flush of pesticides and their transformation products in a Mediterranean catchment
  2. Interacting effects of pollination, water and nutrients on fruit tree performance
  3. Recognition of a WCAM Settlement in Germany
  4. Institutionalisierung der erziehungswissenschaftlichen Lehrerausbildung
  5. Performativität und Diskurs
  6. Incorporating the social-ecological approach in protected areas in the anthropocene
  7. Common opossum population density in an agroforestry system in Bolivia
  8. WikiEvents - A Novel Resource for NLP Downstream Tasks
  9. What are mycorrhizal traits?
  10. Der Körper auf Tauchstation
  11. Modeling strategic electricity storage
  12. Rein oder nachhaltig rein? 
  13. Art as entertainment
  14. 44 VwGO: objektive Klagehäufung
  15. Ausschreibungen
  16. On inhomogeneous Bernoulli convolutions and random power series
  17. Machen Kinder doch glücklich?
  18. Der Guattari-Deleuze-Effekt
  19. Mehr Strategie wagen
  20. Das rationale Regime? Zur Entpolitisierung syrischer Geflüchteter in der deutschen Asylrechtsprechung
  21. Peer-Netzwerke und Freundschaften in der Ganztagsschule
  22. Web Tool for the Identification of Industrial Symbioses in Industrial Parks
  23. Mit dem kulturellen Blick auf den Weg zu einer nachhaltigen Entwicklung
  24. Religionsunterricht
  25. Staatsorganisation
  26. On the way to a Post-Carbon Society
  27. Freiheit in Abhängigkeit
  28. Emotional states of drivers and the impact on driving behaviour - a simulator study
  29. Exploring the Corporate Practice of Sustainability Accounting
  30. Expertise zur Lehrerprofessionalität in Zeiten der Schulentwicklung