GREENER Pharmaceuticals for More Sustainable Healthcare

Publikation: Beiträge in ZeitschriftenÜbersichtsarbeitenForschung


Medicines are essential to human health but can also impact the aquatic and terrestrial environment after use by patients and release via excreta into wastewater. We highlight the need for a GREENER approach to identify and meet important environmental criteria, which will help reduce the impact of medicinal residues on the environment. These criteria include effect reduction by avoiding nontarget effects or undesirable moieties, exposure reduction via lower emissions or environmental (bio)degradability, no PBT (persistent, bioaccumulative, and toxic) substances, and risk mitigation. With all of these criteria, however, patient health is of primary importance as medicines are required to be safe and efficacious for treating diseases. We discuss the feasibility of including these criteria for green by design active pharmaceutical ingredients in the process of drug discovery and development and which tools or assays are needed to accomplish this. The integrated GREENER approach can be used to accelerate discussions about future innovations in drug discovery and development.

ZeitschriftEnvironmental Science and Technology Letters
Seiten (von - bis)699-705
Anzahl der Seiten7
PublikationsstatusErschienen - 13.09.2022

Bibliographische Notiz

Funding Information:
PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement 875508. This Joint Undertaking (JU) receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA ( ). This publication reflects only the authors’ view, and the JU is not responsible for any use that may be made of the information it contains. The authors acknowledge the PREMIER team who discussed the concept and reviewed earlier versions of the paper.

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