Environmental risk assessment of anti-cancer drugs and their transformation products: a focus on their genotoxicity characterization-state of knowledge and short comings

Publikation: Beiträge in ZeitschriftenÜbersichtsarbeitenForschung

Authors

Anti-cancer drugs are chemotherapeutic agents that are designed to kill or reduce proliferating cells. Often times, they interfere directly or indirectly with the cell's deoxyribonucleic acid (DNA). Some of these drugs can be detected in the ng/L concentration range in the aquatic environment and have the potential to be very persistent. Environmental risk assessment is available for only a few anti-cancer drugs, derived mainly from predicted data and excluding information on their metabolites and transformation products (TPs). Notably, there is no defined strategy for genotoxicity risk assessment of anti-cancer drugs, their metabolites and TPs in the environment. In fact, the presence of anti-cancer drugs in hospital and municipal wastewaters has not been clearly related to the genotoxic nature of these wastewaters. The few available studies that have sought to investigate the genotoxicity of mixtures derived from treating anti-cancer drugs prior to disposal seem to share the commonality of coupling analytical methods to measure concentration and genotoxic bioassays, namely the Ames test to monitor inactivation. Such limited studies on the environmental fate and effects of these drugs presents an area for further research work. Most importantly, there is a need to characterize the genotoxic effects of anti-cancer drugs towards aquatic organisms. Given current environmental risk assessment strategies, genotoxicity risk assessment of these drugs and their TPs would have to include a combination of appropriate analytical methods, genotoxicity bioassays, (bio) degradability and computer based prediction methods such as QSAR studies.

OriginalspracheEnglisch
ZeitschriftMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Jahrgang760
Seiten (von - bis)18-35
Anzahl der Seiten18
ISSN0027-5107
DOIs
PublikationsstatusErschienen - 01.04.2014

DOI

Zuletzt angesehen

Forschende

  1. Barbara Ehbauer

Publikationen

  1. Problemlösen in der pädagogischen psychologie
  2. Effects of free air carbon dioxide enrichment and nitrogen supply on growth and yield of winter barley cultivated in a crop rotation
  3. Kohlenstoffdynamik und organische Substanz in Ackerböden
  4. Zahlen, Größen, Räume
  5. Förderung der Gender Diversity bei der Zusammensetzung des Aufsichtsrats
  6. Die veränderte Gesellschaft
  7. Arable vegetation of calcareous soils (Caucalidion) Plant community of the year 2022
  8. Influence of Ultrasound on Friction Induced Vibrations during Tightening of Bolted Joints
  9. Die Dokumentarische Methode und ihr Potenzial für die Erforschung eines (inter)kulturell ausgerichteten Fremdsprachenunterrichts
  10. Kriegsvergessenheit in der Mediengesellschaft
  11. Gute Aufgaben im Mathematikunterricht der Grundschule
  12. Social Conflicts on Agro-Biotechnology
  13. Hannah Wilke
  14. Illness, Dying and Death in Life and Writing of European Writers, vol 1, The 18th and 19th Centuries, vol 2, The 20th and 21st Centuries
  15. Verlust des Randes
  16. Sammelrezension: Nils Berkemeyer/Wilfried Bos/Veronika Manitius/Kathrin Müthing (Hrsg.): Unterrichtsentwicklung in Netzwerken. Konzeptionen, Befunde, Perspektiven. Münster: Waxmann 2008
  17. Economic/ecological tradeoffs among ecosystem services and biodiversity conservation
  18. Future ecosystem service provision under land-use change scenarios in southwestern Ethiopia
  19. Macht und Ohnmacht in Medienkulturen
  20. Assessing the impact of patient-involvement healthcare strategies on patients, providers, and the healthcare system
  21. Ordnungsverantwortung in Demokratie und Marktwirtschaft
  22. Über die Freiheit der Kunst
  23. Untersuchung des Abbaus der Zytostatika Ifosfamid und Cyclophosphamid mit dem Closed Bottle test (OECD 301).
  24. Tunesische Transformationen
  25. Kuba: Wettlauf um viele Welten auf einer Insel
  26. Research on the social perception of invasive species
  27. The Role of Accountants in Controlling Sustainability Information
  28. Unternehmerische Nachhaltigkeitskommunikation
  29. Medien in deutschdidaktischer Perspektive
  30. Two-Dimensional Simulations of Laser Shock Peening of Aluminum with Water Confinement
  31. Der Delfin als Medium. Formation und Imagination in John C Lillys Kommunikationsexperimenten
  32. Business Models for Sustainability
  33. Hegemonie. Politische Theorie nach Antonio Gramsci
  34. Virtuelle Realitäten zur Kompetenzentwicklung und Reflexion in der universitären Lehrkräftebildung am Beispiel von Elterngesprächen
  35. Strengthening gender justice in a just transition
  36. Erlebnismarketing auf Destinationswebsites