Does Internet-based guided self-help for depression cause harm?: An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials

David Daniel Ebert; L. Donkin; Gerhard Andersson; G. Andrews; Thomas K. Berger; Per Carlbring; Alexander Rozental; I. Choi; Johannes A. C. Laferton; Robert Johansson; Annet Kleiboer; Alfred Lange; Dirk Lehr; Jo Annika Reins; Burkhardt Funk; J. Newby; S. Perini; Heleen Riper; Jeroen Ruwaard; L. Sheeber; Frank Snoek; Nickolai Titov; Burcin Ünlü Ince; K.M.P. Van Bastelaar; Kristofer Vernmark; Annemieke Van Straten; L. Warmerdam; N. Salsman; Pim Cuijpers

doi:10.1017/S0033291716001562

Does Internet-based guided self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials

Publikation: Beiträge in Zeitschriften › Übersichtsarbeiten › Forschung

Standard

Does Internet-based guided self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials. / Ebert, David Daniel; Donkin, L.; Andersson, Gerhard et al.
in: Psychological Medicine, Jahrgang 46, Nr. 13, 01.10.2016, S. 2679-2693.

Publikation: Beiträge in Zeitschriften › Übersichtsarbeiten › Forschung

Harvard

Ebert, DD, Donkin, L, Andersson, G, Andrews, G, Berger, TK, Carlbring, P, Rozental, A, Choi, I, Laferton, JAC, Johansson, R, Kleiboer, A, Lange, A, Lehr, D, Reins, JA, Funk, B, Newby, J, Perini, S, Riper, H, Ruwaard, J, Sheeber, L, Snoek, F, Titov, N, Ünlü Ince, B, Van Bastelaar, KMP, Vernmark, K, Van Straten, A, Warmerdam, L, Salsman, N & Cuijpers, P 2016, 'Does Internet-based guided self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials', Psychological Medicine, Jg. 46, Nr. 13, S. 2679-2693. https://doi.org/10.1017/S0033291716001562

APA

Ebert, D. D., Donkin, L., Andersson, G., Andrews, G., Berger, T. K., Carlbring, P., Rozental, A., Choi, I., Laferton, J. A. C., Johansson, R., Kleiboer, A., Lange, A., Lehr, D., Reins, J. A., Funk, B., Newby, J., Perini, S., Riper, H., Ruwaard, J., ... Cuijpers, P. (2016). Does Internet-based guided self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials. Psychological Medicine, 46(13), 2679-2693. https://doi.org/10.1017/S0033291716001562

Vancouver

Ebert DD, Donkin L, Andersson G, Andrews G, Berger TK, Carlbring P et al. Does Internet-based guided self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials. Psychological Medicine. 2016 Okt 1;46(13):2679-2693. doi: 10.1017/S0033291716001562

Bibtex

@article{8963d0e9e8594a0cba0a9b6d09c4b300,

title = "Does Internet-based guided self-help for depression cause harm?: An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials",

abstract = "BackgroundAlmost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-analyses (IPDMA) approach.MethodStudies were identified through systematic searches (PubMed, PsycINFO, EMBASE, Cochrane Library). Deterioration in participants was defined as a significant symptom increase according to the reliable change index (i.e. 7.68 points in the CES-D; 7.63 points in the BDI). Two-step IPDMA procedures, with a random-effects model were used to pool data.ResultsA total of 18 studies (21 comparisons, 2079 participants) contributed data to the analysis. The risk for a reliable deterioration from baseline to post-treatment was significantly lower in the intervention v. control conditions (3.36 v. 7.60; relative risk 0.47, 95% confidence interval 0.29–0.75). Education moderated effects on deterioration, with patients with low education displaying a higher risk for deterioration than patients with higher education. Deterioration rates for patients with low education did not differ statistically significantly between intervention and control groups. The benefit–risk ratio for patients with low education indicated that 9.38 patients achieve a treatment response for each patient experiencing a symptom deterioration.ConclusionsInternet-based guided self-help is associated with a mean reduced risk for a symptom deterioration compared to controls. Treatment and symptom progress of patients with low education should be closely monitored, as some patients might face an increased risk for symptom deterioration. Future studies should examine predictors of deterioration in patients with low education.",

keywords = "Psychology, adverse events, depression, deterioration effect, Internet-based guided self-help, negative effects, Digital media",

author = "Ebert, {David Daniel} and L. Donkin and Gerhard Andersson and G. Andrews and Berger, {Thomas K.} and Per Carlbring and Alexander Rozental and I. Choi and Laferton, {Johannes A. C.} and Robert Johansson and Annet Kleiboer and Alfred Lange and Dirk Lehr and Reins, {Jo Annika} and Burkhardt Funk and J. Newby and S. Perini and Heleen Riper and Jeroen Ruwaard and L. Sheeber and Frank Snoek and Nickolai Titov and {{\"U}nl{\"u} Ince}, Burcin and {Van Bastelaar}, K.M.P. and Kristofer Vernmark and {Van Straten}, Annemieke and L. Warmerdam and N. Salsman and Pim Cuijpers",

year = "2016",

month = oct,

day = "1",

doi = "10.1017/S0033291716001562",

language = "English",

volume = "46",

pages = "2679--2693",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

number = "13",

}

RIS

TY - JOUR

T1 - Does Internet-based guided self-help for depression cause harm?

T2 - An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials

AU - Ebert, David Daniel

AU - Donkin, L.

AU - Andersson, Gerhard

AU - Andrews, G.

AU - Berger, Thomas K.

AU - Carlbring, Per

AU - Rozental, Alexander

AU - Choi, I.

AU - Laferton, Johannes A. C.

AU - Johansson, Robert

AU - Kleiboer, Annet

AU - Lange, Alfred

AU - Lehr, Dirk

AU - Reins, Jo Annika

AU - Funk, Burkhardt

AU - Newby, J.

AU - Perini, S.

AU - Riper, Heleen

AU - Ruwaard, Jeroen

AU - Sheeber, L.

AU - Snoek, Frank

AU - Titov, Nickolai

AU - Ünlü Ince, Burcin

AU - Van Bastelaar, K.M.P.

AU - Vernmark, Kristofer

AU - Van Straten, Annemieke

AU - Warmerdam, L.

AU - Salsman, N.

AU - Cuijpers, Pim

PY - 2016/10/1

Y1 - 2016/10/1

N2 - BackgroundAlmost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-analyses (IPDMA) approach.MethodStudies were identified through systematic searches (PubMed, PsycINFO, EMBASE, Cochrane Library). Deterioration in participants was defined as a significant symptom increase according to the reliable change index (i.e. 7.68 points in the CES-D; 7.63 points in the BDI). Two-step IPDMA procedures, with a random-effects model were used to pool data.ResultsA total of 18 studies (21 comparisons, 2079 participants) contributed data to the analysis. The risk for a reliable deterioration from baseline to post-treatment was significantly lower in the intervention v. control conditions (3.36 v. 7.60; relative risk 0.47, 95% confidence interval 0.29–0.75). Education moderated effects on deterioration, with patients with low education displaying a higher risk for deterioration than patients with higher education. Deterioration rates for patients with low education did not differ statistically significantly between intervention and control groups. The benefit–risk ratio for patients with low education indicated that 9.38 patients achieve a treatment response for each patient experiencing a symptom deterioration.ConclusionsInternet-based guided self-help is associated with a mean reduced risk for a symptom deterioration compared to controls. Treatment and symptom progress of patients with low education should be closely monitored, as some patients might face an increased risk for symptom deterioration. Future studies should examine predictors of deterioration in patients with low education.

AB - BackgroundAlmost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-analyses (IPDMA) approach.MethodStudies were identified through systematic searches (PubMed, PsycINFO, EMBASE, Cochrane Library). Deterioration in participants was defined as a significant symptom increase according to the reliable change index (i.e. 7.68 points in the CES-D; 7.63 points in the BDI). Two-step IPDMA procedures, with a random-effects model were used to pool data.ResultsA total of 18 studies (21 comparisons, 2079 participants) contributed data to the analysis. The risk for a reliable deterioration from baseline to post-treatment was significantly lower in the intervention v. control conditions (3.36 v. 7.60; relative risk 0.47, 95% confidence interval 0.29–0.75). Education moderated effects on deterioration, with patients with low education displaying a higher risk for deterioration than patients with higher education. Deterioration rates for patients with low education did not differ statistically significantly between intervention and control groups. The benefit–risk ratio for patients with low education indicated that 9.38 patients achieve a treatment response for each patient experiencing a symptom deterioration.ConclusionsInternet-based guided self-help is associated with a mean reduced risk for a symptom deterioration compared to controls. Treatment and symptom progress of patients with low education should be closely monitored, as some patients might face an increased risk for symptom deterioration. Future studies should examine predictors of deterioration in patients with low education.

KW - Psychology

KW - adverse events

KW - depression

KW - deterioration effect

KW - Internet-based guided self-help

KW - negative effects

KW - Digital media

UR - http://www.scopus.com/inward/record.url?scp=84988346199&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/7e40f27a-6b70-3c1d-a45d-bc8d4e3d62d3/

U2 - 10.1017/S0033291716001562

DO - 10.1017/S0033291716001562

M3 - Scientific review articles

C2 - 27649340

VL - 46

SP - 2679

EP - 2693

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 13

ER -

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