A combination of dissimilar AA7075/6060 aluminum alloys benefits the advantages of high strength and good corrosion resistance in one hybrid component. Static compound casting using appropriate casting conditions can achieve intermetallic bonding at the interface of the core AA7075 and sleeve AA6060. The inhomogeneous bonding due to non-uniform thermal conditions during static compound casting can be eliminated by the following co-extrusion procedure. Direct hot extrusion of compound-cast AA7075/6060 bilayer billets at a temperature of 420, 450, and 480 °C is conducted to analyze the influence of extrusion temperature on the interfacial bonding. The evolution of the interfacial bonding properties at different extrusion temperatures of as-cast billets is depicted by light optical metallography and mechanical push-out test.