Business experimentation is a key avenue for accelerating change for sustainability. In contrast to experimentation in natural sciences, benefitting from controlled situations, business experimentation aims to explore the diverse possibilities that a business could create value from, or understand what works in which particular situations in a real life business context. While at present most popular with start-ups, this paper argues that large businesses can also find inspiration in business experimentation to develop sustainable business models and accelerate positive change for sustainability. Five illustrative cases are included of business experimentation for sustainability by focusing on pivots (modifications) in the business model. This paper only scratches the surface of the potential impactful new research field of business (model) experimentation for sustainability. Future work on sustainable business experimentation for start-ups and mature businesses is viewed as a powerful future research avenue to accelerate change in industries.