Load-adjusted, weight-optimized components can be fabricated by following a multi-material approach. Integrating the respective advantages of strength and corrosion resistance of Al 7075 and Al 6060 into a single structural component leads to a complex property profile. Compound casting offers a high potential in terms of process chain shortening, material efficiency and bonding quality. The present paper focuses on the production of aluminum bilayer billets by multi-step, discontinuous compound casting. Process conditions influencing the formation of a cohesive bond at the interface are investigated. A fundamental thermal analysis is conducted in order to fully characterize the casting alloys. A process window for metallurgical bonding of Al 7075 and Al 6060 can be defined using a combined approach of process parameters and thermophysical data. The primary bonding mechanism is found to be the epitaxial solidification which occurs through remelting and recrystallization of the substrate alloy. Here the dendrite coherence point constitutes a critical level of the near-interface substrate temperature in terms of forming a solid solution. Epitaxy, phase composition and intermetallic diffusion processes are analyzed using SEM–EDS.