Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells

Jürgen Kleinschmidt; Oliver Müller; Martin Trepel; Felix Kaul; Christoph Leder

Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells

Research output: Patents › Patent

Standard

Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells. / Kleinschmidt, Jürgen; Müller, Oliver; Trepel, Martin et al.
WIPO - Weltorganisation für geistiges Eigentum. Patent No.: WO 2004083441. Sept 30, 2004.

Research output: Patents › Patent

Harvard

Kleinschmidt, J, Müller, O, Trepel, M, Kaul, F & Leder, C Sept. 30 2004, Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells, Patent No. WO 2004083441.

APA

Kleinschmidt, J., Müller, O., Trepel, M., Kaul, F., & Leder, C. (2004). Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells. (Patent No. WO 2004083441). WIPO - Weltorganisation für geistiges Eigentum.

Vancouver

Kleinschmidt J, Müller O, Trepel M, Kaul F, Leder C. Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells. WO 2004083441. 2004 Sept 30.

Bibtex

@misc{2f35a26fc97b43609dbb738567b006eb,

title = "Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells",

abstract = "Described is a method of producing a repertoire of random peptides on the surface of AAV particles wherein said random peptides are expressed as a fusion with an AAV capsid protein of an AAV particle which displays at its surface said random polypeptides. Also described is a peptide library obtainable by said method as well as a method of selecting a gene therapy vector specific for a desired cell type comprising the steps of (a) infecting the desired cell type with a peptide library of the invention and (b) harvesting AAV library particles from the supernatant and/or cell lysates. Finally, AAV vectors obtained by said method are described which are useful for gene therapy, e.g., AAV vectors targeting primary human coronary artery endothelial cells which are suitable for the treatment of diseases associated with a dysfunction of said cells.",

keywords = "Chemistry",

author = "J{\"u}rgen Kleinschmidt and Oliver M{\"u}ller and Martin Trepel and Felix Kaul and Christoph Leder",

year = "2004",

month = sep,

day = "30",

language = "English",

publisher = "WIPO - Weltorganisation f{\"u}r geistiges Eigentum",

address = "Switzerland",

type = "Patent",

note = "WO 2004083441; C12N 15/10 (2006.01),PCT/EP2004/002923 ",

}

RIS

TY - PAT

T1 - Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells

AU - Kleinschmidt, Jürgen

AU - Müller, Oliver

AU - Trepel, Martin

AU - Kaul, Felix

AU - Leder, Christoph

PY - 2004/9/30

Y1 - 2004/9/30

N2 - Described is a method of producing a repertoire of random peptides on the surface of AAV particles wherein said random peptides are expressed as a fusion with an AAV capsid protein of an AAV particle which displays at its surface said random polypeptides. Also described is a peptide library obtainable by said method as well as a method of selecting a gene therapy vector specific for a desired cell type comprising the steps of (a) infecting the desired cell type with a peptide library of the invention and (b) harvesting AAV library particles from the supernatant and/or cell lysates. Finally, AAV vectors obtained by said method are described which are useful for gene therapy, e.g., AAV vectors targeting primary human coronary artery endothelial cells which are suitable for the treatment of diseases associated with a dysfunction of said cells.

AB - Described is a method of producing a repertoire of random peptides on the surface of AAV particles wherein said random peptides are expressed as a fusion with an AAV capsid protein of an AAV particle which displays at its surface said random polypeptides. Also described is a peptide library obtainable by said method as well as a method of selecting a gene therapy vector specific for a desired cell type comprising the steps of (a) infecting the desired cell type with a peptide library of the invention and (b) harvesting AAV library particles from the supernatant and/or cell lysates. Finally, AAV vectors obtained by said method are described which are useful for gene therapy, e.g., AAV vectors targeting primary human coronary artery endothelial cells which are suitable for the treatment of diseases associated with a dysfunction of said cells.

KW - Chemistry

UR - https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2004083441

M3 - Patent

M1 - WO 2004083441

Y2 - 2004/03/19

PB - WIPO - Weltorganisation für geistiges Eigentum

ER -