The core of medicine and care is assisting patients with their health-related problems achieving the best results possible. Yet, recent Information Systems (IS) literature describes patient centered IS healthcare as “supporting assistants with IS”. In need of the patient in the center of the digital transformation process in healthcare, we focus our study on examining the IS scientific community’s contribution to digital healthcare regarding patients in the digital transformation process. We conducted an explorative, systematic but selective review of journal articles published in the best Senior Scholar Journals of the Association of Information Systems. Our results reveal a) a framework for digital health research in IS indicating underrepresented research directions, and b) three propositions on patient centricity in IS healthcare focusing on patient enablement, empowerment, and engagement as central streams.