Is excess mortality higher in depressed men than in depressed women? A meta-analytic comparison

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Is excess mortality higher in depressed men than in depressed women? A meta-analytic comparison. / Cuijpers, Pim; Vogelzangs, Nicole; Twisk, Jos et al.
In: Journal of Affective Disorders, Vol. 161, 01.06.2014, p. 47-54.

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Cuijpers P, Vogelzangs N, Twisk J, Kleiboer A, Li J, Penninx BW. Is excess mortality higher in depressed men than in depressed women? A meta-analytic comparison. Journal of Affective Disorders. 2014 Jun 1;161:47-54. doi: 10.1016/j.jad.2014.03.003

Bibtex

@article{3dcc46099f564f8fabedc7d07f7bbc2f,
title = "Is excess mortality higher in depressed men than in depressed women?: A meta-analytic comparison",
abstract = "Background It is not well-established whether excess mortality associated with depression is higher in men than in women. Methods We conducted a meta-analysis of prospective studies in which depression was measured at baseline, where mortality rates were reported at follow-up, and in which separate mortality rates for men and women were reported. We conducted systematic searches in bibliographical databases and calculated relative risks of excess mortality in men and women. Results Thirteen studies were included. Among the people with depression, excess mortality in men was higher than in women (RR=1.97; 1.63-2.37). Compared with non-depressed participants, excess mortality was increased in depressed women (RR=1.55; 95% CI: 1.32-1.82), but not as much as in men (RR=2.04; 95% CI: 1.76-2.37), and the difference between excess mortality in men was significantly higher than in women (p<0.05). Conclusions Excess mortality related to depression is higher in men than in women. Although the exact mechanisms for this difference are not clear, it may point at differential or more intensified pathways leading from depression to increased mortality in depressed men compared to women.",
keywords = "Health sciences, Depression, Gender difference, Meta-analysis, Mortality, Prospective studies",
author = "Pim Cuijpers and Nicole Vogelzangs and Jos Twisk and Annet Kleiboer and Juan Li and Penninx, {Brenda W.}",
year = "2014",
month = jun,
day = "1",
doi = "10.1016/j.jad.2014.03.003",
language = "English",
volume = "161",
pages = "47--54",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier B.V.",

}

RIS

TY - JOUR

T1 - Is excess mortality higher in depressed men than in depressed women?

T2 - A meta-analytic comparison

AU - Cuijpers, Pim

AU - Vogelzangs, Nicole

AU - Twisk, Jos

AU - Kleiboer, Annet

AU - Li, Juan

AU - Penninx, Brenda W.

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Background It is not well-established whether excess mortality associated with depression is higher in men than in women. Methods We conducted a meta-analysis of prospective studies in which depression was measured at baseline, where mortality rates were reported at follow-up, and in which separate mortality rates for men and women were reported. We conducted systematic searches in bibliographical databases and calculated relative risks of excess mortality in men and women. Results Thirteen studies were included. Among the people with depression, excess mortality in men was higher than in women (RR=1.97; 1.63-2.37). Compared with non-depressed participants, excess mortality was increased in depressed women (RR=1.55; 95% CI: 1.32-1.82), but not as much as in men (RR=2.04; 95% CI: 1.76-2.37), and the difference between excess mortality in men was significantly higher than in women (p<0.05). Conclusions Excess mortality related to depression is higher in men than in women. Although the exact mechanisms for this difference are not clear, it may point at differential or more intensified pathways leading from depression to increased mortality in depressed men compared to women.

AB - Background It is not well-established whether excess mortality associated with depression is higher in men than in women. Methods We conducted a meta-analysis of prospective studies in which depression was measured at baseline, where mortality rates were reported at follow-up, and in which separate mortality rates for men and women were reported. We conducted systematic searches in bibliographical databases and calculated relative risks of excess mortality in men and women. Results Thirteen studies were included. Among the people with depression, excess mortality in men was higher than in women (RR=1.97; 1.63-2.37). Compared with non-depressed participants, excess mortality was increased in depressed women (RR=1.55; 95% CI: 1.32-1.82), but not as much as in men (RR=2.04; 95% CI: 1.76-2.37), and the difference between excess mortality in men was significantly higher than in women (p<0.05). Conclusions Excess mortality related to depression is higher in men than in women. Although the exact mechanisms for this difference are not clear, it may point at differential or more intensified pathways leading from depression to increased mortality in depressed men compared to women.

KW - Health sciences

KW - Depression

KW - Gender difference

KW - Meta-analysis

KW - Mortality

KW - Prospective studies

UR - http://www.scopus.com/inward/record.url?scp=84897557717&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2014.03.003

DO - 10.1016/j.jad.2014.03.003

M3 - Scientific review articles

C2 - 24751307

AN - SCOPUS:84897557717

VL - 161

SP - 47

EP - 54

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -