Ion release from magnesium materials in physiological solutions under different oxygen tensions
Research output: Journal contributions › Journal articles › Research › peer-review
Standard
Ion release from magnesium materials in physiological solutions under different oxygen tensions. / Feyerabend, Frank; Drücker, Heiko; Laipple, Daniel et al.
In: Journal of Materials Science: Materials in Medicine, Vol. 23, No. 1, 01.2012, p. 9-24.Research output: Journal contributions › Journal articles › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Ion release from magnesium materials in physiological solutions under different oxygen tensions
AU - Feyerabend, Frank
AU - Drücker, Heiko
AU - Laipple, Daniel
AU - Vogt, Carla
AU - Stekker, Michael
AU - Hort, Norbert
AU - Willumeit, Regine
PY - 2012/1
Y1 - 2012/1
N2 - Although magnesium as degradable biomaterial already showed clinical proof of concepts, the design of new alloys requires predictive in vitro methods, which are still lacking. Incubation under cell culture conditions to obtain "physiological" corrosion may be a solution. The aim of this study was to analyse the influence of different solutions, addition of proteins and of oxygen availability on the corrosion of different magnesium materials (pure Mg, WE43, and E11) with different surface finishing. Oxygen content in solution, pH, osmolality and ion release were determined. Corrosion led to a reduction of oxygen in solution. The influence of oxygen on pH was enhanced by proteins, while osmolality was not influenced. Magnesium ion release was solution-dependent and enhanced in the initial phase by proteins with delayed release of alloying elements. The main corrosion product formed was magnesium carbonate. Therefore, cell culture conditions are proposed as first step toward physiological corrosion.
AB - Although magnesium as degradable biomaterial already showed clinical proof of concepts, the design of new alloys requires predictive in vitro methods, which are still lacking. Incubation under cell culture conditions to obtain "physiological" corrosion may be a solution. The aim of this study was to analyse the influence of different solutions, addition of proteins and of oxygen availability on the corrosion of different magnesium materials (pure Mg, WE43, and E11) with different surface finishing. Oxygen content in solution, pH, osmolality and ion release were determined. Corrosion led to a reduction of oxygen in solution. The influence of oxygen on pH was enhanced by proteins, while osmolality was not influenced. Magnesium ion release was solution-dependent and enhanced in the initial phase by proteins with delayed release of alloying elements. The main corrosion product formed was magnesium carbonate. Therefore, cell culture conditions are proposed as first step toward physiological corrosion.
KW - Engineering
UR - http://www.scopus.com/inward/record.url?scp=84857626243&partnerID=8YFLogxK
U2 - 10.1007/s10856-011-4490-5
DO - 10.1007/s10856-011-4490-5
M3 - Journal articles
C2 - 22138756
AN - SCOPUS:84857626243
VL - 23
SP - 9
EP - 24
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 1
ER -