Influence of the Microstructure and Silver Content on Degradation, Cytocompatibility, and Antibacterial Properties of Magnesium-Silver Alloys in Vitro

Research output: Journal contributionsJournal articlesResearchpeer-review

Authors

  • Zhidan Liu
  • Ronald Schade
  • Bérengère Luthringer
  • Norbert Hort
  • Holger Rothe
  • Sören Müller
  • Klaus Liefeith
  • Regine Willumeit-Römer
  • Frank Feyerabend

Implantation is a frequent procedure in orthopedic surgery, particularly in the aging population. However, it possesses the risk of infection and biofilm formation at the surgical site. This can cause unnecessary suffering to patients and burden on the healthcare system. Pure Mg, as a promising metal for biodegradable orthopedic implants, exhibits some antibacterial effects due to the alkaline pH produced during degradation. However, this antibacterial effect may not be sufficient in a dynamic environment, for example, the human body. The aim of this study was to increase the antibacterial properties under harsh and dynamic conditions by alloying silver metal with pure Mg as much as possible. Meanwhile, the Mg-Ag alloys should not show obvious cytotoxicity to human primary osteoblasts. Therefore, we studied the influence of the microstructure and the silver content on the degradation behavior, cytocompatibility, and antibacterial properties of Mg-Ag alloys in vitro. The results indicated that a higher silver content can increase the degradation rate of Mg-Ag alloys. However, the degradation rate could be reduced by eliminating the precipitates in the Mg-Ag alloys via T4 treatment. By controlling the microstructure and increasing the silver content, Mg-Ag alloys obtained good antibacterial properties in harsh and dynamic conditions but had almost equivalent cytocompatibility to human primary osteoblasts as pure Mg.

Original languageEnglish
Article number8091265
JournalOxidative Medicine and Cellular Longevity
Volume2017
Number of pages14
ISSN1942-0900
DOIs
Publication statusPublished - 22.06.2017
Externally publishedYes

Bibliographical note

Zhidan Liu thanks the financial support of CSC (China Scholarship Council). The research leading to these results received funding from the Helmholtz Virtual Institute "In vivo studies of biodegradable magnesium based implant materials (MetBioMat)" underGrant agreement no. VH-VI-523.

DOI

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