In vivo degradation of binary magnesium alloys - A long-term study

Research output: Journal contributionsJournal articlesResearchpeer-review

Standard

In vivo degradation of binary magnesium alloys - A long-term study. / Myrissa, Anastasia; Martinelli, Elisabeth; Szakács, Gábor et al.
In: BioNanoMaterials, Vol. 17, No. 3-4, 01.09.2016, p. 121-130.

Research output: Journal contributionsJournal articlesResearchpeer-review

Harvard

Myrissa, A, Martinelli, E, Szakács, G, Berger, L, Eichler, J, Fischerauer, SF, Kleinhans, C, Hort, N, Schäfer, U & Weinberg, AM 2016, 'In vivo degradation of binary magnesium alloys - A long-term study', BioNanoMaterials, vol. 17, no. 3-4, pp. 121-130. https://doi.org/10.1515/bnm-2016-0006

APA

Myrissa, A., Martinelli, E., Szakács, G., Berger, L., Eichler, J., Fischerauer, S. F., Kleinhans, C., Hort, N., Schäfer, U., & Weinberg, A. M. (2016). In vivo degradation of binary magnesium alloys - A long-term study. BioNanoMaterials, 17(3-4), 121-130. https://doi.org/10.1515/bnm-2016-0006

Vancouver

Myrissa A, Martinelli E, Szakács G, Berger L, Eichler J, Fischerauer SF et al. In vivo degradation of binary magnesium alloys - A long-term study. BioNanoMaterials. 2016 Sept 1;17(3-4):121-130. doi: 10.1515/bnm-2016-0006

Bibtex

@article{d0a96e258c5c44b7b2877a52eca44a1d,
title = "In vivo degradation of binary magnesium alloys - A long-term study",
abstract = "Bioresorbable magnesium materials are widely investigated because of their promising properties as orthopedic devices. Pure magnesium (99.99%) and two binary magnesium alloys (Mg2Ag and Mg10Gd) were used to investigate the degradation behavior, the bone adherence and bone-implant interface mechanics of these materials in growing Sprague-Dawley{\textregistered} rats in a long-term study of 36 weeks. In vivo micro-computed tomography (μCT) scans were performed at specific time points to observe the longitudinal degradation of each alloy within the same animal. Pin volume and surface, gas volume and degradation rates were calculated. The results showed a slower degradation of pure magnesium and Mg2Ag in comparison to the fast disintegrating Mg10Gd. Changes in bone morphology were determined by high resolution ex vivo μCT scans and bone sections stained with Toluidine blue. Pure magnesium and Mg2Ag were well integrated and surrounded by bony tissue 24 weeks after implantation. On the contrary, Mg10Gd remnants were surrounded by fibrous and bone tissue. Push-out tests revealed higher bone-implant-interface strengths of pure magnesium pins compared to Mg2Ag and Mg10Gd. Mg10Gd induces less beneficial tissue reactions, while Mg2Ag showed adequate biodegradation and no adverse reactions in bone healing process which might be promising as an orthopedic device.",
keywords = "animal model, gadolinium, magnesium implants, silver, μCT, Engineering",
author = "Anastasia Myrissa and Elisabeth Martinelli and G{\'a}bor Szak{\'a}cs and Leopold Berger and Johannes Eichler and Fischerauer, {Stefan F.} and Claudia Kleinhans and Norbert Hort and Ute Sch{\"a}fer and Weinberg, {Annelie M.}",
year = "2016",
month = sep,
day = "1",
doi = "10.1515/bnm-2016-0006",
language = "English",
volume = "17",
pages = "121--130",
journal = "BioNanoMaterials",
issn = "2193-0651",
publisher = "Walter de Gruyter GmbH",
number = "3-4",

}

RIS

TY - JOUR

T1 - In vivo degradation of binary magnesium alloys - A long-term study

AU - Myrissa, Anastasia

AU - Martinelli, Elisabeth

AU - Szakács, Gábor

AU - Berger, Leopold

AU - Eichler, Johannes

AU - Fischerauer, Stefan F.

AU - Kleinhans, Claudia

AU - Hort, Norbert

AU - Schäfer, Ute

AU - Weinberg, Annelie M.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Bioresorbable magnesium materials are widely investigated because of their promising properties as orthopedic devices. Pure magnesium (99.99%) and two binary magnesium alloys (Mg2Ag and Mg10Gd) were used to investigate the degradation behavior, the bone adherence and bone-implant interface mechanics of these materials in growing Sprague-Dawley® rats in a long-term study of 36 weeks. In vivo micro-computed tomography (μCT) scans were performed at specific time points to observe the longitudinal degradation of each alloy within the same animal. Pin volume and surface, gas volume and degradation rates were calculated. The results showed a slower degradation of pure magnesium and Mg2Ag in comparison to the fast disintegrating Mg10Gd. Changes in bone morphology were determined by high resolution ex vivo μCT scans and bone sections stained with Toluidine blue. Pure magnesium and Mg2Ag were well integrated and surrounded by bony tissue 24 weeks after implantation. On the contrary, Mg10Gd remnants were surrounded by fibrous and bone tissue. Push-out tests revealed higher bone-implant-interface strengths of pure magnesium pins compared to Mg2Ag and Mg10Gd. Mg10Gd induces less beneficial tissue reactions, while Mg2Ag showed adequate biodegradation and no adverse reactions in bone healing process which might be promising as an orthopedic device.

AB - Bioresorbable magnesium materials are widely investigated because of their promising properties as orthopedic devices. Pure magnesium (99.99%) and two binary magnesium alloys (Mg2Ag and Mg10Gd) were used to investigate the degradation behavior, the bone adherence and bone-implant interface mechanics of these materials in growing Sprague-Dawley® rats in a long-term study of 36 weeks. In vivo micro-computed tomography (μCT) scans were performed at specific time points to observe the longitudinal degradation of each alloy within the same animal. Pin volume and surface, gas volume and degradation rates were calculated. The results showed a slower degradation of pure magnesium and Mg2Ag in comparison to the fast disintegrating Mg10Gd. Changes in bone morphology were determined by high resolution ex vivo μCT scans and bone sections stained with Toluidine blue. Pure magnesium and Mg2Ag were well integrated and surrounded by bony tissue 24 weeks after implantation. On the contrary, Mg10Gd remnants were surrounded by fibrous and bone tissue. Push-out tests revealed higher bone-implant-interface strengths of pure magnesium pins compared to Mg2Ag and Mg10Gd. Mg10Gd induces less beneficial tissue reactions, while Mg2Ag showed adequate biodegradation and no adverse reactions in bone healing process which might be promising as an orthopedic device.

KW - animal model

KW - gadolinium

KW - magnesium implants

KW - silver

KW - μCT

KW - Engineering

UR - http://www.scopus.com/inward/record.url?scp=84996567031&partnerID=8YFLogxK

U2 - 10.1515/bnm-2016-0006

DO - 10.1515/bnm-2016-0006

M3 - Journal articles

AN - SCOPUS:84996567031

VL - 17

SP - 121

EP - 130

JO - BioNanoMaterials

JF - BioNanoMaterials

SN - 2193-0651

IS - 3-4

ER -

DOI