Differential mortality rates in major and subthreshold depression: meta-analysis of studies that measured both
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Differential mortality rates in major and subthreshold depression : meta-analysis of studies that measured both. / Cuijpers, Pim; Vogelzangs, Nicole; Twisk, Jos et al.
In: The British Journal of Psychiatry, Vol. 202, No. 1, 01.2013, p. 22-27.Research output: Journal contributions › Scientific review articles › Research
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TY - JOUR
T1 - Differential mortality rates in major and subthreshold depression
T2 - meta-analysis of studies that measured both
AU - Cuijpers, Pim
AU - Vogelzangs, Nicole
AU - Twisk, Jos
AU - Kleiboer, Annet
AU - Li, Juan
AU - Penninx, Brenda W.
PY - 2013/1
Y1 - 2013/1
N2 - BackgroundAlthough the association between depression and excess mortality has been well established, it is not clear whether this is greater in major depression than in subthreshold depression.AimsTo compare excess mortality in major depression with that in subthreshold depression.MethodWe searched bibliographic databases and included prospective studies in which both major and subthreshold depression were examined at baseline and mortality was measured at follow-up.ResultsA total of 22 studies were included. People with major depression had a somewhat increased chance of dying earlier than people with subthreshold depression but this difference was not significant, although there was a trend (relative risk 1.13, 95% CI 0.98–1.30, P = 0.1). The population attributable fraction was 7% for major depression and an additional 7% for subthreshold depression.ConclusionsAlthough excess mortality may be somewhat higher in major than in subthreshold depression, the difference is small and the overall impact on excess mortality is comparable.
AB - BackgroundAlthough the association between depression and excess mortality has been well established, it is not clear whether this is greater in major depression than in subthreshold depression.AimsTo compare excess mortality in major depression with that in subthreshold depression.MethodWe searched bibliographic databases and included prospective studies in which both major and subthreshold depression were examined at baseline and mortality was measured at follow-up.ResultsA total of 22 studies were included. People with major depression had a somewhat increased chance of dying earlier than people with subthreshold depression but this difference was not significant, although there was a trend (relative risk 1.13, 95% CI 0.98–1.30, P = 0.1). The population attributable fraction was 7% for major depression and an additional 7% for subthreshold depression.ConclusionsAlthough excess mortality may be somewhat higher in major than in subthreshold depression, the difference is small and the overall impact on excess mortality is comparable.
KW - Health sciences
KW - Psychology
UR - http://www.scopus.com/inward/record.url?scp=84872165916&partnerID=8YFLogxK
U2 - 10.1192/bjp.bp.112.112169
DO - 10.1192/bjp.bp.112.112169
M3 - Scientific review articles
C2 - 23284149
VL - 202
SP - 22
EP - 27
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - 1
ER -