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Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice.

Research output: Journal contributions › Journal articles › Research › peer-review

Standard

Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. / Leder, Christoph; Schwab, Nicholas ; Wang Ip, Chi et al.
In: Molecular and Cellular Neuroscience, Vol. 36, No. 3, 01.11.2007, p. 416-424.

Research output: Journal contributions › Journal articles › Research › peer-review

Harvard

Leder, C, Schwab, N, Wang Ip, C, Kroner, A, Nave, K-A, Dornmaier, K, Martini, R & Wiendl, H 2007, 'Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice.', Molecular and Cellular Neuroscience, vol. 36, no. 3, pp. 416-424. https://doi.org/10.1016/j.mcn.2007.08.002

APA

Leder, C., Schwab, N., Wang Ip, C., Kroner, A., Nave, K.-A., Dornmaier, K., Martini, R., & Wiendl, H. (2007). Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Molecular and Cellular Neuroscience, 36(3), 416-424. https://doi.org/10.1016/j.mcn.2007.08.002

Vancouver

Leder C, Schwab N, Wang Ip C, Kroner A, Nave KA, Dornmaier K et al. Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Molecular and Cellular Neuroscience. 2007 Nov 1;36(3):416-424. doi: 10.1016/j.mcn.2007.08.002

Bibtex

@article{1345be2879e340508b1c006c5fcc8670,
title = "Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice.",
abstract = "Tissue damage in the CNS is critically influenced by the adaptive immune system. Primary oligodendrocyte damage (by overexpression of PLP) leads to low-grade inflammation of high pathological impact, which is mediated by CD8+ T cells. To yield further insight into pathogenesis and nature of immune responses in myelin mutated mice, we here apply a detailed immunological characterization of CD8+ T cells in PLP-transgenic and aged wild type mice. We provide evidence that T effector cells accumulate in the CNS of PLP-transgenic and wild-type mice and show a higher level of activation in mutant mice, indicated by surface markers and clonal expansions, as demonstrated by T cell receptor CDR3-spectratype analysis. Vβ-Jβ similarities suggest specificity against a common antigen, albeit we could not find specific responses against myelin-antigen-derived peptides. The association of primary oligodendrocyte damage with secondary expansions of pathogenic cells underlines the role of adaptive immune reactions in neurodegenerative and neuroinflammatory diseases.",
keywords = "Biology, PLP, Oligodendrocyte damage, Inframmation, CD8+ T-Cells, Clonal expansion, Multiple sclerosis",
author = "Christoph Leder and Nicholas Schwab and {Wang Ip}, Chi and Antje Kroner and Klaus-Armin Nave and K. Dornmaier and Rudolf Martini and Heinz Wiendl",
year = "2007",
month = nov,
day = "1",
doi = "10.1016/j.mcn.2007.08.002",
language = "English",
volume = "36",
pages = "416--424",
journal = "Molecular and Cellular Neuroscience",
issn = "1095-9327",
publisher = "Elsevier B.V.",
number = "3",

}

RIS

TY - JOUR

T1 - Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice.

AU - Leder, Christoph

AU - Schwab, Nicholas

AU - Wang Ip, Chi

AU - Kroner, Antje

AU - Nave, Klaus-Armin

AU - Dornmaier, K.

AU - Martini, Rudolf

AU - Wiendl, Heinz

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Tissue damage in the CNS is critically influenced by the adaptive immune system. Primary oligodendrocyte damage (by overexpression of PLP) leads to low-grade inflammation of high pathological impact, which is mediated by CD8+ T cells. To yield further insight into pathogenesis and nature of immune responses in myelin mutated mice, we here apply a detailed immunological characterization of CD8+ T cells in PLP-transgenic and aged wild type mice. We provide evidence that T effector cells accumulate in the CNS of PLP-transgenic and wild-type mice and show a higher level of activation in mutant mice, indicated by surface markers and clonal expansions, as demonstrated by T cell receptor CDR3-spectratype analysis. Vβ-Jβ similarities suggest specificity against a common antigen, albeit we could not find specific responses against myelin-antigen-derived peptides. The association of primary oligodendrocyte damage with secondary expansions of pathogenic cells underlines the role of adaptive immune reactions in neurodegenerative and neuroinflammatory diseases.

AB - Tissue damage in the CNS is critically influenced by the adaptive immune system. Primary oligodendrocyte damage (by overexpression of PLP) leads to low-grade inflammation of high pathological impact, which is mediated by CD8+ T cells. To yield further insight into pathogenesis and nature of immune responses in myelin mutated mice, we here apply a detailed immunological characterization of CD8+ T cells in PLP-transgenic and aged wild type mice. We provide evidence that T effector cells accumulate in the CNS of PLP-transgenic and wild-type mice and show a higher level of activation in mutant mice, indicated by surface markers and clonal expansions, as demonstrated by T cell receptor CDR3-spectratype analysis. Vβ-Jβ similarities suggest specificity against a common antigen, albeit we could not find specific responses against myelin-antigen-derived peptides. The association of primary oligodendrocyte damage with secondary expansions of pathogenic cells underlines the role of adaptive immune reactions in neurodegenerative and neuroinflammatory diseases.

KW - Biology

KW - PLP

KW - Oligodendrocyte damage

KW - Inframmation

KW - CD8+ T-Cells

KW - Clonal expansion

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=35449001021&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/37cae56f-b2c5-348c-abbf-06dd04543681/

U2 - 10.1016/j.mcn.2007.08.002

DO - 10.1016/j.mcn.2007.08.002

M3 - Journal articles

VL - 36

SP - 416

EP - 424

JO - Molecular and Cellular Neuroscience

JF - Molecular and Cellular Neuroscience

SN - 1095-9327

IS - 3

ER -

DOI