Professorship for Sustainable Chemistry and Material Resources
Organisational unit: Section
Organisation profile
RESEARCH AND TEACHING
Chair for Sustainable Chemistry and Material Resources
We research and train in the field of sustainable chemistry and pharmacy.
We focus on environmental questions as well as on sustainable questions going beyond that such as social and ecological aspects in the context of the life cycle of chemical substances and products. This includes the extraction of raw material, its use as well as the fate after its use. We are also interested in the material flow associated with the extraction and use of the raw material. On top of the experimental work and modeling, we also develop concepts as for example Benign by Design intended dissipation.
Our research and teaching is carried out on an intra- and transdisciplinary scale within the Faculty of Sustainability together with national and international co-operations.
Topics
We are interested in environmental affairs and all questions concerning the sustainability within the context of the life cycle of chemicals, starting with the raw material itself and going on to the synthesis, the use to end up with the environmental fate of chemical substances and products after their use. Beyond the chemical substances and products themselves, we are also interested in the associated material flows, especially when it comes to the so-called strategic resources (e. g. phosphate, seldom metals).
We investigate the fate (e. g. identification of relevant sources) in the environment as well as the spread and the behavior of chemicals (e. g. spread, biological and photochemical degradation) in the aquatic environment in the sense of a sustainable water management. This is why we want to record their effects (e. g. genotoxicity, mutagenity, and bacteria toxicity).At present we are focusing on pesticides, pharmaceuticals, textile auxiliary agents and nanoparticles.
Service offers
Examination of (bio)-degradability of chemicals and pharmaceuticals
according to OECD/DIN/ISO and others:
• Closed Bottle-Test (OECD 301 D)
• Manometric Respirometry (OECD 301 F)
• Zahn-Wellens-Test (OECD 302 B)
• Waste water treatment plant simulation (OECD 303 A)
• Water Sediment Test
• Photochemical degradation
• Photocatalytic degradation
• Electro coalugation
• and other
Toxicity
Acute and chronic toxicity in bacteria:
• Luminescent bacteria test with Vibrio fischeri (30 minutes and 20h)
• Growth-inhibition test with Pseudomonas putida (16h) and Vibrio fischeri (20h)
• Growth-inhibition test with Enteroccus faecalis
Genotoxicity:
• Ames-Test with Salmonella typhimurium TA 98/TA 100
• Umu-Test with Salmonella typhimurium TA 1535/ psK 1002
• Mikronucleus-Test with CHO-Cells by FACS-Analysis
• Green Screen-Assay with TK6-cells
Chemical informatics
Structure property relationships
• Calculation of physicochemical properties of molecules
• Calculation of quantum chemical parameters of molecules
• Calculation of toxicity and mutagenicity
• Calculation of the biological degradation
• Calculation of metabolites (mammalia bacteria)
• Targeted design of chemicals and pharmaceuticals
• Support in purchasing decisions
• Product optimization
• REACH
Water flux based reactive mass transport modelling and assessment
• Spatio-temporal analysis of discharge and water quality (R-Statistics, SigmaPlot, ArcGIS)
• Assessment of water quality by combined water quality and quantity indices (WQI, WQQI, WAI)
• Water quality modelling in lakes and reservoirs in 1D, 2D and 3D (LAC, MOHID Water, Ce-qual)
• Catchment modelling of hydrology, erosion and sedimenttransport, phosphorus discharge, pesticides and transformation product discharge (ZIN-Sed, MOHID Land, reservoir models)
• River channel modelling of water, sediment, phosphorus, pesticide and transformation product discharge (ZIN-Sed, MOHID Stream)
• Scenario modelling and assessment
• System analysis and management assessment
• Integrated water ressources management
Analytics
• Liquid chromatography coupled to ion trap mass spectrometry
• HPLC with UV and fluorescence detection
• Gas chromatography coupled to mass spectrometry
• Ion chromatography
- Published
Lipids in preventive dentistry
Kensche, A., Reich, M., Kümmerer, K., Hannig, M. & Hannig, C., 04.2013, In: Clinical Oral Investigations. 17, 3, p. 669-685 17 p.Research output: Journal contributions › Scientific review articles › Research
- Published
Biodegradation potential of ofloxacin and its resulting transformation products during photolytic and photocatalytic treatment
Vasquez, M., Hapeshi, E., Fatta-Kassinos, D. & Kümmerer, K., 03.2013, In: Environmental Science and Pollution Research. 20, 3, p. 1302-1309 8 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
aCD133-GPVI: A bifunctional protein for imroved stent performance and endothelial regeneration
Baumer, Y., Leder, C., Schönberger, T., Ziegler, M., Filzmayer, C., Bühring, H-J. & Gawaz, M., 2011, In: Tissue Engineering Part A. 17, 3/4, p. 554 1 p.Research output: Journal contributions › Conference abstract in journal › Research
- Published
Multivariate Optimization of Analytical Methodology and a First Attempt to an Environmental Risk Assessment of β-Blockers in Hospital Wastewater
Wilde, M. L., Kümmerer, K. & Martins, A. F., 25.09.2012, In: Journal of the Brazilian Chemical Society. 23, 9, p. 1732-1740 9 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Das Fettsäureprofil des initialen oralen Biofilms (Pellikel) - eine In-situ-Studie
Reich, M., Hannig, C., Al-Ahmad, A. & Kümmerer, K., 04.2012, In: Deutsche Zahnärztliche Zeitschrift. 67, 4, p. D18 1 p.Research output: Journal contributions › Conference abstract in journal › Research › peer-review
- Published
Modification of the umu-assay (ISO 13829) accounting for cytotoxicity in genotoxicity assessment: A preliminary study
Toolaram, A. P., Gutiérrez, I. R. & Ahlf, W., 18.09.2012, In: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 747, 2, p. 190-196 7 p.Research output: Journal contributions › Journal articles › Research
- Published
Basin efficiency approach and its effect on streamflow quality, Zerafshan River Uzbekistan
Olsson, O., Gassmann, M., Manig, N., Ikramova, M. & Wegerich, K., 07.01.2013, In: Journal of Hydrology. 476, 7, p. 128–135 8 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Fate of Pesticides and Their Transformation Products: First Flush Effects in a Semi-Arid Catchment
Olsson, O., Khodorkovsky, M., Gassmann, M., Friedler, E., Schneider, M. & Dubowski, Y., 02.2013, In: Clean - Soil, Air, Water. 41, 2, p. 134-142 9 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Hydraulic Fracturing: Zusammensetzung und Entsorgung anfallender Abwässer
Olsson, O., Weichgrebe, D. & Rosenwinkel, K-H., 09.2012, In: Wasser und Abfall. 14, 9, p. 10-15 6 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
A comprehensive method for determination of fatty acids in the initial oral biofilm (pellicle)
Reich, M., Hannig, C., Al-Ahmad, A., Bolek, R. & Kuemmerer, K., 01.10.2012, In: Journal of Lipid Research. 53, 10, p. 2226-2230 5 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Random peptide library displayed on AAV vectors targeting human primary coronary artery endothelial cells
Kleinschmidt, J., Müller, O., Trepel, M., Kaul, F. & Leder, C., 30.09.2004, IPC No. C12N 15/10 (2006.01), PCT/EP2004/002923 , WIPO - Weltorganisation für geistiges Eigentum, Patent No. WO 2004083441, 19.03.2004, Priority date 19.03.2003Research output: Patents › Patent
- Published
Methods and compositions relating to a vaccine against prostate cancer
Leder, C., King, A. D., Pavlenko, M. & Pisa, P., 04.01.2007, IPC No. A61K39/00 (2006.01), Patent No. WO/2007/002149 A2, 21.06.2006Research output: Patents › Patent
- Published
Fusionsprotein und dessen Verwendungen
Leder, C., Gawaz, M., Ziegler, M. & Stellos, K., 06.10.2011, IPC No. DE 102010013887A1, Deutsches Patent- und Markenamt, 30.03.2010Research output: Patents › Patent
- Published
Gremlin fusion products with immunoglobulin Fc domains and their use as antiinflammatories or immunomodulators
Gawaz, M., Müller, I., Leder, C. & Filzmayer, C., 24.05.2012, IPC No. DE 102010052941A1, Deutsches Patent- und Markenamt, 18.11.2010, Priority date 24.05.2012Research output: Patents › Patent
- Published
1002 Pharmacokinetic studies on a novel HBV entry inhibitor Myrcludex B demonstrate HBV-receptor expression in rodents and dogs but not in cynomolgus monkeys
Schieck, A., Meier, A., Alexandrov, A., Leder, C., Romeis, P., Haberkorn, U., Mier, J. W. & Urban, S., 01.04.2010, In: Journal of Hepatology. 51, 1, p. S387 1 p.Research output: Journal contributions › Conference abstract in journal › Research › peer-review
- Published
Bifunctional recombinant protein SDF1-GPVI as a new therapeutic concept for improved regeneration
Ziegler, M., Baumer, Y., Leder, C., Schönberger, T., Elvers, M., Schlosshauer, B. & Gawaz, M., 02.2011, BioStar 2010 - Science in Exchange: Meeting Abstracts. TERMIS, p. 553-554 2 p. (Tissue Engineering Part A; vol. 17, no. 3/4).Research output: Contributions to collected editions/works › Published abstract in conference proceedings › Research › peer-review
- Published
The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice.
Ziegler, M., Elvers, M., Baumer, Y., Leder, C., Ochmann, C., Schönberger, T., Jürgens, T., Geisler, T., Schlosshauer, B., Lunov, O., Engelhardt, S., Simmet, T. & Gawaz, M., 07.02.2012, In: Circulation. 125, 5, p. 685-696 12 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
The recombinant bifunctional protein αCD133–GPVI promotes repair of the infarcted myocardium in mice
Baumer, Y., Leder, C., Ziegler, M., Schönberger, T., Ochmann, C., Perk, A., Degen, H., Schmid-Horch, B., Elvers, M., Münch, G., Ungerer, M., Schlosshauer, B. & Gawaz, M., 06.2012, In: Journal of Thrombosis and Haemostasis . 10, 6, p. 1152-1164 13 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Elution of monomers from three different bonding systems and their antibacterial effect
Polydorou, O., Rogatti, P., Bolek, R., Wolkewitz, M., Kümmerer, K. & Hellwig, E., 07.2013, In: Odontology / the Society of the Nippon Dental University. 101, 2, p. 170-176 7 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Ready biodegradability of trifluoromethylated phenothiazine drugs, structural elucidation of their aquatic transformation products, and identification of environmental risks studied by LC-MS( n ) and QSAR
Trautwein, C. & Kümmerer, K., 09.2012, In: Environmental Science and Pollution Research. 19, 8, p. 3162-3177 16 p.Research output: Journal contributions › Journal articles › Research › peer-review