Tormentil for active ulcerative colitis: An Open-Label, Dose-Escalating Study

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Standard

Tormentil for active ulcerative colitis: An Open-Label, Dose-Escalating Study. / Huber, Roman; von Ditfurth, Amelie; Amann, Frank et al.
in: Journal of Clinical Gastroenterology, Jahrgang 41, Nr. 9, 01.10.2007, S. 834-838.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Harvard

Huber, R, von Ditfurth, A, Amann, F, Güthlin, C, Rostock, M, Trittler, R, Kümmerer, K & Merfort, I 2007, 'Tormentil for active ulcerative colitis: An Open-Label, Dose-Escalating Study', Journal of Clinical Gastroenterology, Jg. 41, Nr. 9, S. 834-838. https://doi.org/10.1097/MCG.0b013e31804b2173

APA

Huber, R., von Ditfurth, A., Amann, F., Güthlin, C., Rostock, M., Trittler, R., Kümmerer, K., & Merfort, I. (2007). Tormentil for active ulcerative colitis: An Open-Label, Dose-Escalating Study. Journal of Clinical Gastroenterology, 41(9), 834-838. https://doi.org/10.1097/MCG.0b013e31804b2173

Vancouver

Huber R, von Ditfurth A, Amann F, Güthlin C, Rostock M, Trittler R et al. Tormentil for active ulcerative colitis: An Open-Label, Dose-Escalating Study. Journal of Clinical Gastroenterology. 2007 Okt 1;41(9):834-838. doi: 10.1097/MCG.0b013e31804b2173

Bibtex

@article{b2e0de7fe4ee4b6790ab5451cd9ffb14,
title = "Tormentil for active ulcerative colitis: An Open-Label, Dose-Escalating Study",
abstract = "BACKGROUND: Tormentil extracts (TE) have antioxidative properties and are used as a complementary therapy for chronic inflammatory bowel disease. In individual patients with ulcerative colitis (UC) positive effects have been observed. GOALS: To assess the safety, pharmacology, and clinical effects of different doses of TE in patients with active UC. STUDY: Sixteen patients with active UC [clinical activity index (CAI) ≥5] received TE in escalating doses of 1200, 1800, 2400 and 3000 mg/d for 3 weeks each. Each treatment phase was followed by a 4-week washout phase. The outcome parameters were side effects, CAI, C-reactive protein, and tannin levels in patient sera. RESULTS: Mild upper abdominal discomfort was experienced by 6 patients (38%), but did not require discontinuation of the medication. During therapy with 2400 mg TE per day, median CAI and C-reactive protein improved from 8 (6 to 10.75) and 8 (3 to 17.75) mg/L at baseline to 4.5 (1.75 to 6) and 3 (3 to 6) mg/L, respectively. During therapy, the CAI decreased in all patients, whereas it increased during the washout phase. Neither undegraded nor metabolized tannins could be detected by liquid-mass spectrometry (LC-MS) in patient sera. CONCLUSIONS: TE appeared safe up to 3000 mg/d. Tannins from TE are not systemically absorbed. The efficacy in patients with UC should be further evaluated.",
keywords = "Chemistry, CAI, Cohort study, Tannins, Ulcerative colitis",
author = "Roman Huber and {von Ditfurth}, Amelie and Frank Amann and Corina G{\"u}thlin and Matthias Rostock and Rainer Trittler and Klaus K{\"u}mmerer and Irmgard Merfort",
year = "2007",
month = oct,
day = "1",
doi = "10.1097/MCG.0b013e31804b2173",
language = "English",
volume = "41",
pages = "834--838",
journal = "Journal of Clinical Gastroenterology",
issn = "0192-0790",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Tormentil for active ulcerative colitis

T2 - An Open-Label, Dose-Escalating Study

AU - Huber, Roman

AU - von Ditfurth, Amelie

AU - Amann, Frank

AU - Güthlin, Corina

AU - Rostock, Matthias

AU - Trittler, Rainer

AU - Kümmerer, Klaus

AU - Merfort, Irmgard

PY - 2007/10/1

Y1 - 2007/10/1

N2 - BACKGROUND: Tormentil extracts (TE) have antioxidative properties and are used as a complementary therapy for chronic inflammatory bowel disease. In individual patients with ulcerative colitis (UC) positive effects have been observed. GOALS: To assess the safety, pharmacology, and clinical effects of different doses of TE in patients with active UC. STUDY: Sixteen patients with active UC [clinical activity index (CAI) ≥5] received TE in escalating doses of 1200, 1800, 2400 and 3000 mg/d for 3 weeks each. Each treatment phase was followed by a 4-week washout phase. The outcome parameters were side effects, CAI, C-reactive protein, and tannin levels in patient sera. RESULTS: Mild upper abdominal discomfort was experienced by 6 patients (38%), but did not require discontinuation of the medication. During therapy with 2400 mg TE per day, median CAI and C-reactive protein improved from 8 (6 to 10.75) and 8 (3 to 17.75) mg/L at baseline to 4.5 (1.75 to 6) and 3 (3 to 6) mg/L, respectively. During therapy, the CAI decreased in all patients, whereas it increased during the washout phase. Neither undegraded nor metabolized tannins could be detected by liquid-mass spectrometry (LC-MS) in patient sera. CONCLUSIONS: TE appeared safe up to 3000 mg/d. Tannins from TE are not systemically absorbed. The efficacy in patients with UC should be further evaluated.

AB - BACKGROUND: Tormentil extracts (TE) have antioxidative properties and are used as a complementary therapy for chronic inflammatory bowel disease. In individual patients with ulcerative colitis (UC) positive effects have been observed. GOALS: To assess the safety, pharmacology, and clinical effects of different doses of TE in patients with active UC. STUDY: Sixteen patients with active UC [clinical activity index (CAI) ≥5] received TE in escalating doses of 1200, 1800, 2400 and 3000 mg/d for 3 weeks each. Each treatment phase was followed by a 4-week washout phase. The outcome parameters were side effects, CAI, C-reactive protein, and tannin levels in patient sera. RESULTS: Mild upper abdominal discomfort was experienced by 6 patients (38%), but did not require discontinuation of the medication. During therapy with 2400 mg TE per day, median CAI and C-reactive protein improved from 8 (6 to 10.75) and 8 (3 to 17.75) mg/L at baseline to 4.5 (1.75 to 6) and 3 (3 to 6) mg/L, respectively. During therapy, the CAI decreased in all patients, whereas it increased during the washout phase. Neither undegraded nor metabolized tannins could be detected by liquid-mass spectrometry (LC-MS) in patient sera. CONCLUSIONS: TE appeared safe up to 3000 mg/d. Tannins from TE are not systemically absorbed. The efficacy in patients with UC should be further evaluated.

KW - Chemistry

KW - CAI

KW - Cohort study

KW - Tannins

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=34548851444&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6e11987b-b0ce-3fa5-95df-cf08a6854a8b/

U2 - 10.1097/MCG.0b013e31804b2173

DO - 10.1097/MCG.0b013e31804b2173

M3 - Journal articles

VL - 41

SP - 834

EP - 838

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

SN - 0192-0790

IS - 9

ER -

DOI

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