In this article, based on a Symposium held at the 2022 Academy of Management Meeting, we present a moderated discussion between established scholars in the field of grand challenges—Shahzad (Shaz) Ansari, Natalie Slawinski, and Eero Vaara—focusing on the role of institutional, paradox, and practice theories in research on grand challenges. Our goal for the symposium was to bring these theoretical perspectives into conversation, reflect on the strengths and weaknesses of the lenses, and discuss potential intersections for future research on grand challenges. We present the panelists’ prepared remarks as well as the interactive discussion covering four topics: the limitations of existing concepts and theories, materiality, impact, and relations between theory and practice. As part of these four discussion topics, we also present questions and reflections from the audience. We conclude by summarizing insights gleaned from the symposium about critical gaps and avenues for future research.