TY - CHAP

T1 - Pharmaceuticals in the Environment — Scope of the Book and Introduction

T2 - Pharmaceuticals in the Environment

AU - Kümmerer, Klaus

PY - 2001

Y1 - 2001

N2 - Pharmaceutically active compounds are complex molecules with different functionalities, physicochemical and biological properties. They are developed and used because of their more or less specific biological activity and are most notably characterised by their ionic nature. Their molecular weights range typically from 300 to 1 000. Under environmental conditions molecules can be neutral, cationic, anionic, or zwitterionic. They also often have basic or acidic functionalities. Pharmaceuticals can be classified according to their effects, but also “crosswise” according to their chemical structure. Normally, pharmaceuticals and disinfectants are classified according to their therapeutical purpose (e.g. antibiotics, analgesics, antineoplastics, anti-inflammatory substances, antibiotics, antihistaminic agents, contrast media, etc.). Classification according to chemical structure is used mainly for the sub-groups of the active substances, e.g. within a group of antibiotics such as β-lactams, cephalosporins, penicillins or quinolones. In such cases, some of the compounds can be treated as groups and one or the other compound can be used as a general example for this group. A closely related chemical structure may be accompanied by an identical or at least a similar mode of action (e.g. antibiotics). However, as the example of antineoplastics shows, it might also be very different: alkylating, antimetabolic, mitosis inhibiting or intercalating substances belong to different classes of chemicals. In other words, compared to most bulk chemicals, pharmaceutically active compounds are often complex molecules with special properties e.g. dependence of log K ow, on pH (see Chap. 2).

AB - Pharmaceutically active compounds are complex molecules with different functionalities, physicochemical and biological properties. They are developed and used because of their more or less specific biological activity and are most notably characterised by their ionic nature. Their molecular weights range typically from 300 to 1 000. Under environmental conditions molecules can be neutral, cationic, anionic, or zwitterionic. They also often have basic or acidic functionalities. Pharmaceuticals can be classified according to their effects, but also “crosswise” according to their chemical structure. Normally, pharmaceuticals and disinfectants are classified according to their therapeutical purpose (e.g. antibiotics, analgesics, antineoplastics, anti-inflammatory substances, antibiotics, antihistaminic agents, contrast media, etc.). Classification according to chemical structure is used mainly for the sub-groups of the active substances, e.g. within a group of antibiotics such as β-lactams, cephalosporins, penicillins or quinolones. In such cases, some of the compounds can be treated as groups and one or the other compound can be used as a general example for this group. A closely related chemical structure may be accompanied by an identical or at least a similar mode of action (e.g. antibiotics). However, as the example of antineoplastics shows, it might also be very different: alkylating, antimetabolic, mitosis inhibiting or intercalating substances belong to different classes of chemicals. In other words, compared to most bulk chemicals, pharmaceutically active compounds are often complex molecules with special properties e.g. dependence of log K ow, on pH (see Chap. 2).

KW - Chemistry

KW - Sewage Sludge

KW - Sewage Treatment Plant

KW - Isocyanuric Acid

KW - Pharmaceutical Residue

KW - Specific Biological Activity

UR - https://www.mendeley.com/catalogue/9c7b946d-0985-3e1e-983e-050552b179aa/

U2 - 10.1007/978-3-662-09259-0_1

DO - 10.1007/978-3-662-09259-0_1

M3 - Contributions to collected editions/anthologies

SN - 3-540-41067-8

SN - 978-3-662-09261-3

SP - 3

EP - 11

BT - Pharmaceuticals in the Environment

A2 - Kümmerer, Klaus

PB - Springer

CY - Berlin

ER -