Digital media today are accompanied by emphatic stances on knowledge, non-knowledge, and their relation to one another. Generating, distributing, and making available massive amounts of data that take form by modeling, digital media provide us with abundant information and potentially new ways of gaining knowledge. This has been attracting various, sometimes radical scenarios in which technology either eliminates nonknowledge or plants it deep within contemporary cultures, due to the alleged universal power and opacity of algorithms. Both conceptualizing and researching non-knowledge have proven to be epistemological challenges that are key to understanding contemporary digital cultures.