TY - JOUR

T1 - In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model

AU - Tie, Di

AU - Hort, Norbert

AU - Chen, Minfang

AU - Guan, Renguo

AU - Ulasevich, Sviatlana

AU - Skorb, Ekaterina V.

AU - Zhao, Dapeng

AU - Liu, Yili

AU - Holt-Torres, Patricia

AU - Liu, Huinan

N1 - This work was supported by National Natural Science Foundation of China (grant numbers 51771045 and U1764254 ). Special thanks are due to the instrumental analysis from Analytical and Testing Center, Northeastern University. The authors sincerely acknowledge the Animal Experimental Center of China Medical University for the in vivo experiments.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge. Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties, adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine model. Attributed to the rheo-solidification process, equiaxial microstructure and significantly refined grains (average grain size: 27.1 μm) were achieved. Mg17Sr2 and Mg4Ag were found as the primary precipitates in the matrix, due to which the alloy obtained ca. 111% increase in ultimate tensile strength in comparison to pure magnesium. Both the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the alloy. Histological evaluation and bioindicators analysis suggested that there was no tissue damage, inflammation and lesions in the urinary system caused by the degradation process. The stent also improved the post-operative bladder functions viewed from the urodynamic results. Our findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material.

AB - A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge. Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties, adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine model. Attributed to the rheo-solidification process, equiaxial microstructure and significantly refined grains (average grain size: 27.1 μm) were achieved. Mg17Sr2 and Mg4Ag were found as the primary precipitates in the matrix, due to which the alloy obtained ca. 111% increase in ultimate tensile strength in comparison to pure magnesium. Both the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the alloy. Histological evaluation and bioindicators analysis suggested that there was no tissue damage, inflammation and lesions in the urinary system caused by the degradation process. The stent also improved the post-operative bladder functions viewed from the urodynamic results. Our findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material.

KW - Biodegradable metals

KW - In vivo

KW - Magnesium alloy

KW - Mechanical properties

KW - Urinary compatibility

KW - Engineering

UR - http://www.scopus.com/inward/record.url?scp=85108512632&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/d577793e-6d96-33aa-8c36-460dc86ee9c2/

U2 - 10.1016/j.bioactmat.2021.05.046

DO - 10.1016/j.bioactmat.2021.05.046

M3 - Journal articles

C2 - 34466731

AN - SCOPUS:85108512632

VL - 7

SP - 254

EP - 262

JO - Bioactive Materials

JF - Bioactive Materials

SN - 2452-199X

ER -