Ceramics are the first choice for orthopaedic, dental and other biomedical applications. Because of the processes used, the conventional production of ceramic parts is moreover limited to materials that are not optimal from a medical point of view. Further critical issues for biomedical applications are cooling lubricants and polishing materials used for machining the ceramics. Absorption into the surface of the machined ceramic parts makes them not neutral for the human body so they can cause allergic reactions or diseases. The developed dry, high speed milling of ceramics (Ceramill) presented in this work solves this problem. The method and a prototype machine tool for 3D treatment with the implementation of advanced controls, CAD-CAM coupling, high speed spindle, the dry process and the dedicated new tools have been developed and approved in field tests. Work pieces with dimensions till 200×400× 400 mm has been constructed. Suitable geometries and coatings for new milling tools have been determined. The machining tests were performed with various parameters such as diamond coating thickness and composition. The trials have been performed with aluminium oxide, zirconium oxide and silicon nitride. Ceramill leads to accurately finished products with tolerances of the order of magnitude of 1 micron and surface roughness of 0.2 microns. First measurements of the Weibull factor for silicon nitride show an encouraging value of 57 by a load of 628 MPa. A first model for the process based on the mechanistic approach has been established on the MatLab platform.