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Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms

Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet

Standard

Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms. / Hadad, Ghada M. ; Emara, Samy ; Mahmoud, Waleed M. M.
in: Talanta, Jahrgang 79, Nr. 5, 15.10.2009, S. 1360-1367.

Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet

Harvard

Hadad, GM, Emara, S & Mahmoud, WMM 2009, 'Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms', Talanta, Jg. 79, Nr. 5, S. 1360-1367. https://doi.org/10.1016/j.talanta.2009.06.003

APA

Hadad, G. M., Emara, S., & Mahmoud, W. M. M. (2009). Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms. Talanta, 79(5), 1360-1367. https://doi.org/10.1016/j.talanta.2009.06.003

Vancouver

Hadad GM, Emara S, Mahmoud WMM. Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms. Talanta. 2009 Okt 15;79(5):1360-1367. doi: 10.1016/j.talanta.2009.06.003

Bibtex

@article{b217c456eb1442adbff4ed6eef18871d,
title = "Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms",
abstract = "A stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method has been developed which can separate and accurately quantitate paracetamol, dantrolene, cetirizine and pseudoephedrine. The method was successfully validated for the purpose of conducting stability studies of the four analytes in quality control (QC) laboratories. The stability-indicating capability of the method was demonstrated by adequate separation of these four analytes from all the degradant peaks. A gradient mobile phase system consisting of (A) 50 mmol L−1 sodium dihydrogen phosphate, 5 mmol L−1 heptane sulfonic acid sodium salt, pH 4.2 and (B) acetonitrile was used with Discovery reversed-phase HS C18 analytical column (250 mm × 4.6 mm i.d., 5 μm particle size). Quantitation was achieved with UV detection at 214 nm, based on peak area.The proposed method was validated and successfully applied for the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing the two multicomponent combinations.",
keywords = "Chemistry, Cetirizine, Dantrolene, Paracetamol, Pseudoephedrine, Reversed-phase HPLC, Stability",
author = "Hadad, {Ghada M.} and Samy Emara and Mahmoud, {Waleed M. M.}",
year = "2009",
month = oct,
day = "15",
doi = "10.1016/j.talanta.2009.06.003",
language = "English",
volume = "79",
pages = "1360--1367",
journal = "Talanta",
issn = "0039-9140",
publisher = "Elsevier B.V.",
number = "5",

}

RIS

TY - JOUR

T1 - Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms

AU - Hadad, Ghada M.

AU - Emara, Samy

AU - Mahmoud, Waleed M. M.

PY - 2009/10/15

Y1 - 2009/10/15

N2 - A stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method has been developed which can separate and accurately quantitate paracetamol, dantrolene, cetirizine and pseudoephedrine. The method was successfully validated for the purpose of conducting stability studies of the four analytes in quality control (QC) laboratories. The stability-indicating capability of the method was demonstrated by adequate separation of these four analytes from all the degradant peaks. A gradient mobile phase system consisting of (A) 50 mmol L−1 sodium dihydrogen phosphate, 5 mmol L−1 heptane sulfonic acid sodium salt, pH 4.2 and (B) acetonitrile was used with Discovery reversed-phase HS C18 analytical column (250 mm × 4.6 mm i.d., 5 μm particle size). Quantitation was achieved with UV detection at 214 nm, based on peak area.The proposed method was validated and successfully applied for the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing the two multicomponent combinations.

AB - A stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method has been developed which can separate and accurately quantitate paracetamol, dantrolene, cetirizine and pseudoephedrine. The method was successfully validated for the purpose of conducting stability studies of the four analytes in quality control (QC) laboratories. The stability-indicating capability of the method was demonstrated by adequate separation of these four analytes from all the degradant peaks. A gradient mobile phase system consisting of (A) 50 mmol L−1 sodium dihydrogen phosphate, 5 mmol L−1 heptane sulfonic acid sodium salt, pH 4.2 and (B) acetonitrile was used with Discovery reversed-phase HS C18 analytical column (250 mm × 4.6 mm i.d., 5 μm particle size). Quantitation was achieved with UV detection at 214 nm, based on peak area.The proposed method was validated and successfully applied for the analysis of pharmaceutical formulations and laboratory-prepared mixtures containing the two multicomponent combinations.

KW - Chemistry

KW - Cetirizine

KW - Dantrolene

KW - Paracetamol

KW - Pseudoephedrine

KW - Reversed-phase HPLC

KW - Stability

UR - http://www.scopus.com/inward/record.url?scp=67650979193&partnerID=8YFLogxK

U2 - 10.1016/j.talanta.2009.06.003

DO - 10.1016/j.talanta.2009.06.003

M3 - Journal articles

C2 - 19635371

VL - 79

SP - 1360

EP - 1367

JO - Talanta

JF - Talanta

SN - 0039-9140

IS - 5

ER -

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