Biodegradable magnesium-hydroxyapatite metal matrix composites

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Standard

Biodegradable magnesium-hydroxyapatite metal matrix composites. / Witte, Frank; Feyerabend, Frank; Maier, Petra et al.
in: Biomaterials, Jahrgang 28, Nr. 13, 05.2007, S. 2163-2174.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Harvard

Witte, F, Feyerabend, F, Maier, P, Fischer, J, Störmer, M, Blawert, C, Dietzel, W & Hort, N 2007, 'Biodegradable magnesium-hydroxyapatite metal matrix composites', Biomaterials, Jg. 28, Nr. 13, S. 2163-2174. https://doi.org/10.1016/j.biomaterials.2006.12.027

APA

Witte, F., Feyerabend, F., Maier, P., Fischer, J., Störmer, M., Blawert, C., Dietzel, W., & Hort, N. (2007). Biodegradable magnesium-hydroxyapatite metal matrix composites. Biomaterials, 28(13), 2163-2174. https://doi.org/10.1016/j.biomaterials.2006.12.027

Vancouver

Witte F, Feyerabend F, Maier P, Fischer J, Störmer M, Blawert C et al. Biodegradable magnesium-hydroxyapatite metal matrix composites. Biomaterials. 2007 Mai;28(13):2163-2174. doi: 10.1016/j.biomaterials.2006.12.027

Bibtex

@article{09ccd31d53c9449b9000ffb1c109cd1a,
title = "Biodegradable magnesium-hydroxyapatite metal matrix composites",
abstract = "Recent studies indicate that there is a high demand to design magnesium alloys with adjustable corrosion rates and suitable mechanical properties. An approach to this challenge might be the application of metal matrix composite (MMC) based on magnesium alloys. In this study, a MMC made of magnesium alloy AZ91D as a matrix and hydroxyapatite (HA) particles as reinforcements have been investigated in vitro for mechanical, corrosive and cytocompatible properties. The mechanical properties of the MMC-HA were adjustable by the choice of HA particle size and distribution. Corrosion tests revealed that HA particles stabilised the corrosion rate and exhibited more uniform corrosion attack in artificial sea water and cell solutions. The phase identification showed that all samples contained hcp-Mg, Mg17Al12, and HA before and after immersion. After immersion in artificial sea water CaCO3 was found on MMC-HA surfaces, while no formation of CaCO3 was found after immersion in cell solutions with and without proteins. Co-cultivation of MMC-HA with human bone derived cells (HBDC), cells of an osteoblasts lineage (MG-63) and cells of a macrophage lineage (RAW264.7) revealed that RAW264.7, MG-63 and HBDC adhere, proliferate and survive on the corroding surfaces of MMC-HA. In summary, biodegradable MMC-HA are cytocompatible biomaterials with adjustable mechanical and corrosive properties.",
keywords = "Corrosion, Cytotoxicity, Hydroxyapatite, Magnesium, Mechanical properties, Metal matrix composite, Engineering",
author = "Frank Witte and Frank Feyerabend and Petra Maier and Jens Fischer and Michael St{\"o}rmer and Carsten Blawert and Wolfgang Dietzel and Norbert Hort",
year = "2007",
month = may,
doi = "10.1016/j.biomaterials.2006.12.027",
language = "English",
volume = "28",
pages = "2163--2174",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier B.V.",
number = "13",

}

RIS

TY - JOUR

T1 - Biodegradable magnesium-hydroxyapatite metal matrix composites

AU - Witte, Frank

AU - Feyerabend, Frank

AU - Maier, Petra

AU - Fischer, Jens

AU - Störmer, Michael

AU - Blawert, Carsten

AU - Dietzel, Wolfgang

AU - Hort, Norbert

PY - 2007/5

Y1 - 2007/5

N2 - Recent studies indicate that there is a high demand to design magnesium alloys with adjustable corrosion rates and suitable mechanical properties. An approach to this challenge might be the application of metal matrix composite (MMC) based on magnesium alloys. In this study, a MMC made of magnesium alloy AZ91D as a matrix and hydroxyapatite (HA) particles as reinforcements have been investigated in vitro for mechanical, corrosive and cytocompatible properties. The mechanical properties of the MMC-HA were adjustable by the choice of HA particle size and distribution. Corrosion tests revealed that HA particles stabilised the corrosion rate and exhibited more uniform corrosion attack in artificial sea water and cell solutions. The phase identification showed that all samples contained hcp-Mg, Mg17Al12, and HA before and after immersion. After immersion in artificial sea water CaCO3 was found on MMC-HA surfaces, while no formation of CaCO3 was found after immersion in cell solutions with and without proteins. Co-cultivation of MMC-HA with human bone derived cells (HBDC), cells of an osteoblasts lineage (MG-63) and cells of a macrophage lineage (RAW264.7) revealed that RAW264.7, MG-63 and HBDC adhere, proliferate and survive on the corroding surfaces of MMC-HA. In summary, biodegradable MMC-HA are cytocompatible biomaterials with adjustable mechanical and corrosive properties.

AB - Recent studies indicate that there is a high demand to design magnesium alloys with adjustable corrosion rates and suitable mechanical properties. An approach to this challenge might be the application of metal matrix composite (MMC) based on magnesium alloys. In this study, a MMC made of magnesium alloy AZ91D as a matrix and hydroxyapatite (HA) particles as reinforcements have been investigated in vitro for mechanical, corrosive and cytocompatible properties. The mechanical properties of the MMC-HA were adjustable by the choice of HA particle size and distribution. Corrosion tests revealed that HA particles stabilised the corrosion rate and exhibited more uniform corrosion attack in artificial sea water and cell solutions. The phase identification showed that all samples contained hcp-Mg, Mg17Al12, and HA before and after immersion. After immersion in artificial sea water CaCO3 was found on MMC-HA surfaces, while no formation of CaCO3 was found after immersion in cell solutions with and without proteins. Co-cultivation of MMC-HA with human bone derived cells (HBDC), cells of an osteoblasts lineage (MG-63) and cells of a macrophage lineage (RAW264.7) revealed that RAW264.7, MG-63 and HBDC adhere, proliferate and survive on the corroding surfaces of MMC-HA. In summary, biodegradable MMC-HA are cytocompatible biomaterials with adjustable mechanical and corrosive properties.

KW - Corrosion

KW - Cytotoxicity

KW - Hydroxyapatite

KW - Magnesium

KW - Mechanical properties

KW - Metal matrix composite

KW - Engineering

UR - http://www.scopus.com/inward/record.url?scp=33846799472&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/0193c196-edcb-3473-a869-3f40989fdb13/

U2 - 10.1016/j.biomaterials.2006.12.027

DO - 10.1016/j.biomaterials.2006.12.027

M3 - Journal articles

C2 - 17276507

AN - SCOPUS:33846799472

VL - 28

SP - 2163

EP - 2174

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 13

ER -