Biodegradable magnesium-hydroxyapatite metal matrix composites
Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet
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Biodegradable magnesium-hydroxyapatite metal matrix composites. / Witte, Frank; Feyerabend, Frank; Maier, Petra et al.
in: Biomaterials, Jahrgang 28, Nr. 13, 05.2007, S. 2163-2174.Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet
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TY - JOUR
T1 - Biodegradable magnesium-hydroxyapatite metal matrix composites
AU - Witte, Frank
AU - Feyerabend, Frank
AU - Maier, Petra
AU - Fischer, Jens
AU - Störmer, Michael
AU - Blawert, Carsten
AU - Dietzel, Wolfgang
AU - Hort, Norbert
PY - 2007/5
Y1 - 2007/5
N2 - Recent studies indicate that there is a high demand to design magnesium alloys with adjustable corrosion rates and suitable mechanical properties. An approach to this challenge might be the application of metal matrix composite (MMC) based on magnesium alloys. In this study, a MMC made of magnesium alloy AZ91D as a matrix and hydroxyapatite (HA) particles as reinforcements have been investigated in vitro for mechanical, corrosive and cytocompatible properties. The mechanical properties of the MMC-HA were adjustable by the choice of HA particle size and distribution. Corrosion tests revealed that HA particles stabilised the corrosion rate and exhibited more uniform corrosion attack in artificial sea water and cell solutions. The phase identification showed that all samples contained hcp-Mg, Mg17Al12, and HA before and after immersion. After immersion in artificial sea water CaCO3 was found on MMC-HA surfaces, while no formation of CaCO3 was found after immersion in cell solutions with and without proteins. Co-cultivation of MMC-HA with human bone derived cells (HBDC), cells of an osteoblasts lineage (MG-63) and cells of a macrophage lineage (RAW264.7) revealed that RAW264.7, MG-63 and HBDC adhere, proliferate and survive on the corroding surfaces of MMC-HA. In summary, biodegradable MMC-HA are cytocompatible biomaterials with adjustable mechanical and corrosive properties.
AB - Recent studies indicate that there is a high demand to design magnesium alloys with adjustable corrosion rates and suitable mechanical properties. An approach to this challenge might be the application of metal matrix composite (MMC) based on magnesium alloys. In this study, a MMC made of magnesium alloy AZ91D as a matrix and hydroxyapatite (HA) particles as reinforcements have been investigated in vitro for mechanical, corrosive and cytocompatible properties. The mechanical properties of the MMC-HA were adjustable by the choice of HA particle size and distribution. Corrosion tests revealed that HA particles stabilised the corrosion rate and exhibited more uniform corrosion attack in artificial sea water and cell solutions. The phase identification showed that all samples contained hcp-Mg, Mg17Al12, and HA before and after immersion. After immersion in artificial sea water CaCO3 was found on MMC-HA surfaces, while no formation of CaCO3 was found after immersion in cell solutions with and without proteins. Co-cultivation of MMC-HA with human bone derived cells (HBDC), cells of an osteoblasts lineage (MG-63) and cells of a macrophage lineage (RAW264.7) revealed that RAW264.7, MG-63 and HBDC adhere, proliferate and survive on the corroding surfaces of MMC-HA. In summary, biodegradable MMC-HA are cytocompatible biomaterials with adjustable mechanical and corrosive properties.
KW - Corrosion
KW - Cytotoxicity
KW - Hydroxyapatite
KW - Magnesium
KW - Mechanical properties
KW - Metal matrix composite
KW - Engineering
UR - http://www.scopus.com/inward/record.url?scp=33846799472&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/0193c196-edcb-3473-a869-3f40989fdb13/
U2 - 10.1016/j.biomaterials.2006.12.027
DO - 10.1016/j.biomaterials.2006.12.027
M3 - Journal articles
C2 - 17276507
AN - SCOPUS:33846799472
VL - 28
SP - 2163
EP - 2174
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 13
ER -