B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschung

Standard

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis. / Ortler, Sonja; Leder, Christoph; Mittelbronn, Michel et al.
in: European Journal of Immunology, Jahrgang 38, Nr. 6, 06.2008, S. 1734-1744.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschung

Harvard

APA

Vancouver

Ortler S, Leder C, Mittelbronn M, Zozulya AL, Knolle PA, Kroner A et al. B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis. European Journal of Immunology. 2008 Jun;38(6):1734-1744. doi: 10.1002/eji.200738071

Bibtex

@article{b8c0f1db499f4cde9edbf2ec662713f5,
title = "B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.",
abstract = "The co-inhibitory B7-homologue 1 (B7-H1/PD-L1) influences adaptive immune responses and has been proposed to contribute to the mechanisms maintaining peripheral tolerance and limiting inflammatory damage in parenchymal organs. To understand the B7-H1/PD1 pathway in CNS inflammation, we analyzed adaptive immune responses in myelin oligodendrocyte glycoprotein (MOG) 35- 55-induced EAE and assessed the expression of B7-H1 in human CNS tissue. B7-H1 -/- mice exhibited an accelerated disease onset and significantly exacerbated EAE severity, although absence of B7-H1 had no influence on MOG antibody production. Peripheral MOG-specific IFN-γ/IL-17 T cell responses occurred earlier and enhanced in B7-H1 -/- mice, but ceased more rapidly. In the CNS, however, significantly higher numbers of activated neuroantigen-specific T cells persisted during all stages of EAE. Experiments showing a direct inhibitory role of APC-derived B7-H1 on the activation of MOG-specific effector cells support the assumption that parenchymal B7-H1 is pivotal for delineating T cell fate in the target organ. Compatible with this concept, our data investigating human brain tissue specimens show a strong up-regulation of B7-H1 in lesions of multiple sclerosis. Our findings demonstrate the critical importance of B7-H1 as an immune-inhibitory molecule capable of down-regulating T cell responses thus contributing to the confinement of immunopathological damage.",
keywords = "Chemistry, Co-stimulation, EAE, Inflammation, MS",
author = "Sonja Ortler and Christoph Leder and Michel Mittelbronn and Zozulya, {Alla L.} and Knolle, {Percy A.} and Antje Kroner and Heinz Wiendl and Lieping Chen",
year = "2008",
month = jun,
doi = "10.1002/eji.200738071",
language = "English",
volume = "38",
pages = "1734--1744",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.

AU - Ortler, Sonja

AU - Leder, Christoph

AU - Mittelbronn, Michel

AU - Zozulya, Alla L.

AU - Knolle, Percy A.

AU - Kroner, Antje

AU - Wiendl, Heinz

AU - Chen, Lieping

PY - 2008/6

Y1 - 2008/6

N2 - The co-inhibitory B7-homologue 1 (B7-H1/PD-L1) influences adaptive immune responses and has been proposed to contribute to the mechanisms maintaining peripheral tolerance and limiting inflammatory damage in parenchymal organs. To understand the B7-H1/PD1 pathway in CNS inflammation, we analyzed adaptive immune responses in myelin oligodendrocyte glycoprotein (MOG) 35- 55-induced EAE and assessed the expression of B7-H1 in human CNS tissue. B7-H1 -/- mice exhibited an accelerated disease onset and significantly exacerbated EAE severity, although absence of B7-H1 had no influence on MOG antibody production. Peripheral MOG-specific IFN-γ/IL-17 T cell responses occurred earlier and enhanced in B7-H1 -/- mice, but ceased more rapidly. In the CNS, however, significantly higher numbers of activated neuroantigen-specific T cells persisted during all stages of EAE. Experiments showing a direct inhibitory role of APC-derived B7-H1 on the activation of MOG-specific effector cells support the assumption that parenchymal B7-H1 is pivotal for delineating T cell fate in the target organ. Compatible with this concept, our data investigating human brain tissue specimens show a strong up-regulation of B7-H1 in lesions of multiple sclerosis. Our findings demonstrate the critical importance of B7-H1 as an immune-inhibitory molecule capable of down-regulating T cell responses thus contributing to the confinement of immunopathological damage.

AB - The co-inhibitory B7-homologue 1 (B7-H1/PD-L1) influences adaptive immune responses and has been proposed to contribute to the mechanisms maintaining peripheral tolerance and limiting inflammatory damage in parenchymal organs. To understand the B7-H1/PD1 pathway in CNS inflammation, we analyzed adaptive immune responses in myelin oligodendrocyte glycoprotein (MOG) 35- 55-induced EAE and assessed the expression of B7-H1 in human CNS tissue. B7-H1 -/- mice exhibited an accelerated disease onset and significantly exacerbated EAE severity, although absence of B7-H1 had no influence on MOG antibody production. Peripheral MOG-specific IFN-γ/IL-17 T cell responses occurred earlier and enhanced in B7-H1 -/- mice, but ceased more rapidly. In the CNS, however, significantly higher numbers of activated neuroantigen-specific T cells persisted during all stages of EAE. Experiments showing a direct inhibitory role of APC-derived B7-H1 on the activation of MOG-specific effector cells support the assumption that parenchymal B7-H1 is pivotal for delineating T cell fate in the target organ. Compatible with this concept, our data investigating human brain tissue specimens show a strong up-regulation of B7-H1 in lesions of multiple sclerosis. Our findings demonstrate the critical importance of B7-H1 as an immune-inhibitory molecule capable of down-regulating T cell responses thus contributing to the confinement of immunopathological damage.

KW - Chemistry

KW - Co-stimulation

KW - EAE

KW - Inflammation

KW - MS

UR - http://www.scopus.com/inward/record.url?scp=49649111913&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/e246980c-d867-3c04-96f8-094c430d852a/

U2 - 10.1002/eji.200738071

DO - 10.1002/eji.200738071

M3 - Journal articles

VL - 38

SP - 1734

EP - 1744

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 6

ER -

DOI

Zuletzt angesehen

Publikationen

  1. Effects of Soil Properties, Temperature and Disturbance on Diversity and Functional Composition of Plant Communities Along a Steep Elevational Gradient on Tenerife
  2. Moving Towards Measuring Multifunctionality in Ecosystems: FieldScreen – A Mobile Positioning System for Non-Invasive Measurement of Plant Traits in Field Experiments
  3. The outcome of coaching and training for self-employment. A statistical evaluation of outside assistance support programs for unemployed business founders in Germany
  4. Reduced nitrate leaching from an Irish cropland soil under non-inversion tillage with cover cropping greatly outweighs increased dissolved organic nitrogen leaching
  5. Design of Reliable Remobilisation Finger Implants with Geometry Elements of a Triple Periodic Minimal Surface Structure via Additive Manufacturing of Silicon Nitride
  6. Is the future still open? The mediating role of occupational future time perspective in the effects of career adaptability and aging experience on late career planning
  7. Die Jahrgangsmischung auf dem Prüfstand: Effekte jahrgangsübergreifenden Lernens auf Kompetenzen und sozio-emotionales Wohlbefinden von Grundschülerinnen und Grundschülern
  8. Evaluation eines Interventionsansatzes zur Verbesserung von Motivation und motivationsförderlichem Unterrichtshandeln von Lehrkräften auf Basis der Zielorientierungstheorie
  9. Determination of the construction and the material identity values of outside building components with the help of in-situ measuring procedures and FEM-simulation calculations
  10. Digitale Gesundheitskompetenz von Studierenden während der COVID-19 Pandemie. Befunde zur Ausprägung und Assoziationen mit Informationszufriedenheit und psychischer Gesundheit
  11. Évaluation du potentiel allélopathique des composés hydrosolubles de l’orge (Hordeum vulgare L. subsp. vulgare) et du grand brome (Bromus diandrus Roth.) moyennant un bio-essai modifié
  12. Increasing personal initiative in small business managers or owners leads to entrepreneurial success: A theory-based controlled randomized field intervention for evidence-based management
  13. Fördert eine videobasierte Intervention im Praktikum die professionelle Wahrnehmung von Klassenführung? – Eine quantitativ-inhaltsanalytische Messung von Subprozessen professioneller Wahrnehmung
  14. Angehende Lehrpersonen der Primar- und Sekundarstufe gestalten inklusiven naturwissenschaftlichen Unterricht – eine Videostudie mit dem Kategoriensystem inklusiver naturwissenschaftlicher Unterricht (KinU)
  15. Wirksamkeit eines internet- und smartphone-basierten Dankbarkeitstrainings zur Förderung der gedanklichen Distanzierung von arbeitsbezogenen Problemen –Sekundäranalyse einer randomisiert - kontrollierten Studie